Profiling the peripheral blood T cell receptor repertoires of gastric cancer patients

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Peng Gao
  • Laifeng Ren
  • Jingjing Duan
  • Silu Yang
  • Haina Wang
  • Hongxia Wang
  • Junning Sun
  • Xiaoyan Gao
  • Bo Li
  • Wen Su

Detail(s)

Original languageEnglish
Article number848113
Number of pages9
Journal / PublicationFrontiers in Immunology
Volume13
Online published28 Jul 2022
Publication statusPublished - 28 Jul 2022

Link(s)

Abstract

Cancer driven by somatic mutations may express neoantigens that can trigger T-cell immune responses. Since T-cell receptor (TCR) repertoires play critical roles in anti-tumor immune responses for oncology, next-generation sequencing (NGS) was used to profile the hypervariable complementarity-determining region 3 (CDR3) of the TCR-beta chain in peripheral blood samples from 68 gastric cancer patients and 49 healthy controls. We found that most hyper-expanded CDR3 are individual-specific, and the gene usage of TRBV3-1 is more frequent in the tumor group regardless of tumor stage than in the healthy control group. We identified 374 hyper-expanded tumor-specific CDR3, which may play a vital role in anti-tumor immune responses. The patients with stage IV gastric cancer have higher EBV-specific CDR3 abundance than the control. In conclusion, analysis of the peripheral blood TCR repertoires may provide the biomarker for gastric cancer prognosis and guide future immunotherapy.

Research Area(s)

  • TCR repertoire analysis, gastric cancer, TCR repertoire, next-generation sequencing, biomarker, antitumor immunity

Citation Format(s)

Profiling the peripheral blood T cell receptor repertoires of gastric cancer patients. / Wang, Mengyao; Gao, Peng; Ren, Laifeng et al.
In: Frontiers in Immunology, Vol. 13, 848113, 28.07.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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