Prodrug Strategies for Paclitaxel

Ziyuan Meng; Quanxia Lv; Jun Lu; Houzong Yao; Xiaoqing Lv; Feng Jiang; Aiping Lu; Ge Zhang

doi:10.3390/ijms17050796

Prodrug Strategies for Paclitaxel

Ziyuan Meng, Quanxia Lv, Jun Lu, Houzong Yao, Xiaoqing Lv, Feng Jiang^*, Aiping Lu^*, Ge Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

86 Citations (Scopus)

48 Downloads (CityUHK Scholars)

Abstract

Paclitaxel is an anti-tumor agent with remarkable anti-tumor activity and wide clinical uses. However, it is also faced with various challenges especially for its poor water solubility and low selectivity for the target. To overcome these disadvantages of paclitaxel, approaches using small molecule modifications and macromolecule modifications have been developed by many research groups from all over the world. In this review, we discuss the different strategies especially prodrug strategies that are currently used to make paclitaxel more effective.

Original language	English
Article number	796
Journal	International Journal of Molecular Sciences
Volume	17
Issue number	5
Online published	23 May 2016
DOIs	https://doi.org/10.3390/ijms17050796
Publication status	Published - 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

paclitaxel
poor water solubility
low selectivity
prodrug

Publisher's Copyright Statement

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license.

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10.3390/ijms17050796

41606534.pdfFinal Published version, 3.46 MBLicence: CC BY

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AU - Meng, Ziyuan

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AU - Lu, Jun

AU - Yao, Houzong

AU - Lv, Xiaoqing

AU - Jiang, Feng

AU - Lu, Aiping

AU - Zhang, Ge

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AB - Paclitaxel is an anti-tumor agent with remarkable anti-tumor activity and wide clinical uses. However, it is also faced with various challenges especially for its poor water solubility and low selectivity for the target. To overcome these disadvantages of paclitaxel, approaches using small molecule modifications and macromolecule modifications have been developed by many research groups from all over the world. In this review, we discuss the different strategies especially prodrug strategies that are currently used to make paclitaxel more effective.

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Prodrug Strategies for Paclitaxel

Abstract

UN SDGs

Research Keywords

Publisher's Copyright Statement

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