Prodrug Strategies for Paclitaxel

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

72 Scopus Citations
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Author(s)

  • Ziyuan Meng
  • Quanxia Lv
  • Jun Lu
  • Xiaoqing Lv
  • Feng Jiang
  • Aiping Lu
  • Ge Zhang

Detail(s)

Original languageEnglish
Article number796
Journal / PublicationInternational Journal of Molecular Sciences
Volume17
Issue number5
Online published23 May 2016
Publication statusPublished - 2016
Externally publishedYes

Link(s)

Abstract

Paclitaxel is an anti-tumor agent with remarkable anti-tumor activity and wide clinical uses. However, it is also faced with various challenges especially for its poor water solubility and low selectivity for the target. To overcome these disadvantages of paclitaxel, approaches using small molecule modifications and macromolecule modifications have been developed by many research groups from all over the world. In this review, we discuss the different strategies especially prodrug strategies that are currently used to make paclitaxel more effective.

Research Area(s)

  • paclitaxel, poor water solubility, low selectivity, prodrug

Citation Format(s)

Prodrug Strategies for Paclitaxel. / Meng, Ziyuan; Lv, Quanxia; Lu, Jun et al.
In: International Journal of Molecular Sciences, Vol. 17, No. 5, 796, 2016.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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