TY - GEN
T1 - Principal component analysis of nucleosome dna conformational data
AU - Yang, Xi
AU - Yan, Hong
PY - 2010
Y1 - 2010
N2 - The deformation mechanism of double helical DNA can be elucidated by the correlations between various conformational properties of its constituent dinucleotides. In this paper, we study the structural features of nucleosomes by performing principle component analysis on structural parameters within three categories: sugar-phosphate backbone, base pairs and base steps. The aim of this study is to find out the coupling modes of these conformational properties which are probably responsible for the special conformational settings of dinucleotides in nucleosomes. For comparison, a number of B-form oligomers are selected and subjected to PCA. Analysis of similarity and difference between nucleosomes and oligomers is implemented. The result shows that nucleosomes have a series of unique coupling patterns and reveals the multidimensioncoordinated deformation mechanisms. © 2010 IEEE.
AB - The deformation mechanism of double helical DNA can be elucidated by the correlations between various conformational properties of its constituent dinucleotides. In this paper, we study the structural features of nucleosomes by performing principle component analysis on structural parameters within three categories: sugar-phosphate backbone, base pairs and base steps. The aim of this study is to find out the coupling modes of these conformational properties which are probably responsible for the special conformational settings of dinucleotides in nucleosomes. For comparison, a number of B-form oligomers are selected and subjected to PCA. Analysis of similarity and difference between nucleosomes and oligomers is implemented. The result shows that nucleosomes have a series of unique coupling patterns and reveals the multidimensioncoordinated deformation mechanisms. © 2010 IEEE.
KW - Conformational properties
KW - Coupling of parameters
KW - Deformation mechanism
KW - Principal component analysis
UR - https://www.scopus.com/pages/publications/78149349616
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-78149349616&origin=recordpage
U2 - 10.1109/ICMLC.2010.5580721
DO - 10.1109/ICMLC.2010.5580721
M3 - RGC 32 - Refereed conference paper (with host publication)
SN - 9781424465262
VL - 6
SP - 3085
EP - 3090
BT - 2010 International Conference on Machine Learning and Cybernetics, ICMLC 2010
T2 - 2010 International Conference on Machine Learning and Cybernetics, ICMLC 2010
Y2 - 11 July 2010 through 14 July 2010
ER -