Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist

Priscilla K. Y. Chan; Savio C. Y. Chan; Wing-Ho Yung

doi:10.1097/00001756-199803090-00020

Author(s)

Priscilla K. Y. Chan
Savio C. Y. Chan
Wing-Ho Yung

Detail(s)

Original language	English
Pages (from-to)	671-675
Journal / Publication	NeuroReport
Volume	9
Issue number	4
Publication status	Published - 9 Mar 1998
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1097/00001756-199803090-00020 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-0032498905&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(e7f102bc-b515-4f7e-aced-07568e81b08f).html

Abstract

Whole-cell patch-clamp recordings were made from substantia nigra pars reticulata (SNR) neurones in rat midbrain slices to investigate the electrophysiological effects of cannabinoids. The cannabinoid receptor agonist WIN 55212-2 =(10 μM) significantly reduced intranigrally evoked and spontaneous inhibitory postsynaptic currents (IPSCs) which were mediated by GABA(A) receptors. The postsynaptic current induced by bath application of GABA was not affected by the presence of WIN 55212-2. The actions of WIN 55212-2 were not mimicked by the inactive enantiomer WIN 55212-3. WIN 55212- 2 also hyperpolarized the membrane of SNR neurones in a tetrodotoxin/0- Ca²⁺-insensitive manner. These data suggest that cannabinoids modulate the activity of SNR neurones by presynaptic inhibition of GABA inputs. They may also exert a direct post-synaptic inhibition on these neurones.

Research Area(s)

Cannabinoid, GABA, IPSC, Substantia nigra

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Citation Format(s)

[ RIS ] [ BibTeX ]

Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist. / Chan, Priscilla K. Y.; Chan, Savio C. Y.; Yung, Wing-Ho.
In: NeuroReport, Vol. 9, No. 4, 09.03.1998, p. 671-675.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Chan, PKY, Chan, SCY & Yung, W-H 1998, 'Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist', NeuroReport, vol. 9, no. 4, pp. 671-675. https://doi.org/10.1097/00001756-199803090-00020

Chan, P. K. Y., Chan, S. C. Y., & Yung, W.-H. (1998). Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist. NeuroReport, 9(4), 671-675. https://doi.org/10.1097/00001756-199803090-00020

Chan PKY, Chan SCY, Yung WH. Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist. NeuroReport. 1998 Mar 9;9(4):671-675. doi: 10.1097/00001756-199803090-00020

Chan, Priscilla K. Y. ; Chan, Savio C. Y. ; Yung, Wing-Ho. / Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist. In: NeuroReport. 1998 ; Vol. 9, No. 4. pp. 671-675.