Preparation of Fe 3O 4/poly(styrene-butyl acrylate-[2-(methacryloxy)ethyl]trimethylammonium chloride) by emulsifier-free emulsion polymerization and its interaction with DNA

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Xiaolong Li
  • Guoqiang Liu
  • Wei Yan
  • Kelvin W.K. Yeung
  • Shuilin Wu
  • Changfeng Yi
  • Zushun Xu

Detail(s)

Original languageEnglish
Pages (from-to)1410-1418
Journal / PublicationJournal of Magnetism and Magnetic Materials
Volume324
Issue number7
Publication statusPublished - Apr 2012

Abstract

Cationic magnetic polymer particles Fe 3O 4/ poly(styrene-butyl acrylate-[2-(methacryloxy)ethyl]trimethylammonium chloride), a type of potential gene carrier, were prepared by emulsifier-free emulsion polymerization with oleic acid modified magnetite Fe 3O 4, styrene, butyl acrylate and [2-(methacryloxy)ethyl]trimethylammonium chloride) (METAC). The morphology of the particles was characterized by transmission electron microscopy and the composites of particles were characterized by FT-IR spectroscopy, X-ray diffraction. These results showed that magnetic particles were well dispersed in polymers with the content of about 15%(wt/wt). The composites exhibited superparamagnetism and possessed a certain level of magnetic response. The interactions between the particles with calf-thymus DNA (ct DNA) were confirmed by zeta potential measurement, UVvis spectroscopy and fluorescence spectroscopy. The DNA-binding capacity determined by the agarose gel electrophoresis showed good binding capacity of the emulsion to DNA. These results suggested the potential of the cationic magnetic polymer emulsion as gene target delivery carrier. © 2011 Elsevier B.V. All rights reserved.

Research Area(s)

  • DNA, Emulsifier-free emulsion polymerization, Fluorescence spectroscopy, Magnetic polymer, Polycations

Citation Format(s)

Preparation of Fe 3O 4/poly(styrene-butyl acrylate-[2-(methacryloxy)ethyl]trimethylammonium chloride) by emulsifier-free emulsion polymerization and its interaction with DNA. / Li, Xiaolong; Liu, Guoqiang; Yan, Wei; Chu, Paul K.; Yeung, Kelvin W.K.; Wu, Shuilin; Yi, Changfeng; Xu, Zushun.

In: Journal of Magnetism and Magnetic Materials, Vol. 324, No. 7, 04.2012, p. 1410-1418.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal