Preferential base pairing modes of T·T mismatches

Guoyun He; Chun Kit Kwok; Sik Lok Lam

doi:10.1016/j.febslet.2011.10.044

Preferential base pairing modes of T·T mismatches

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Overview

15 Scopus Citations

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Author(s)

Guoyun He
Chun Kit Kwok
Sik Lok Lam

Detail(s)

Original language	English
Pages (from-to)	3953-3958
Journal / Publication	FEBS Letters
Volume	585
Issue number	24
Publication status	Published - 15 Dec 2011
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.febslet.2011.10.044 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-82555186948&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(92a4c668-01a5-4b8b-a64c-6ae1af601551).html

Abstract

It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.