Preferential base pairing modes of T·T mismatches

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

17 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)3953-3958
Journal / PublicationFEBS Letters
Volume585
Issue number24
Publication statusPublished - 15 Dec 2011
Externally publishedYes

Abstract

It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Research Area(s)

  • Base pairing mode, DNA, NMR, T·T mismatch

Citation Format(s)

Preferential base pairing modes of T·T mismatches. / He, Guoyun; Kwok, Chun Kit; Lam, Sik Lok.
In: FEBS Letters, Vol. 585, No. 24, 15.12.2011, p. 3953-3958.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review