Preferential base pairing modes of T·T mismatches
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 3953-3958 |
Journal / Publication | FEBS Letters |
Volume | 585 |
Issue number | 24 |
Publication status | Published - 15 Dec 2011 |
Externally published | Yes |
Link(s)
Abstract
It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Research Area(s)
- Base pairing mode, DNA, NMR, T·T mismatch
Citation Format(s)
Preferential base pairing modes of T·T mismatches. / He, Guoyun; Kwok, Chun Kit; Lam, Sik Lok.
In: FEBS Letters, Vol. 585, No. 24, 15.12.2011, p. 3953-3958.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review