Preferential base pairing modes of T·T mismatches

Guoyun He; Chun Kit Kwok; Sik Lok Lam

doi:10.1016/j.febslet.2011.10.044

Preferential base pairing modes of T·T mismatches

Guoyun He, Chun Kit Kwok, Sik Lok Lam^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

19 Citations (Scopus)

Abstract

It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	3953-3958
Journal	FEBS Letters
Volume	585
Issue number	24
DOIs	https://doi.org/10.1016/j.febslet.2011.10.044
Publication status	Published - 15 Dec 2011
Externally published	Yes

Research Keywords

Base pairing mode
DNA
NMR
T·T mismatch

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title = "Preferential base pairing modes of T·T mismatches",

abstract = "It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs. {\textcopyright} 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",

keywords = "Base pairing mode, DNA, NMR, T·T mismatch",

author = "Guoyun He and Kwok, {Chun Kit} and Lam, {Sik Lok}",

year = "2011",

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doi = "10.1016/j.febslet.2011.10.044",

language = "English",

volume = "585",

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journal = "FEBS Letters",

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TY - JOUR

T1 - Preferential base pairing modes of T·T mismatches

AU - He, Guoyun

AU - Kwok, Chun Kit

AU - Lam, Sik Lok

PY - 2011/12/15

Y1 - 2011/12/15

N2 - It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

KW - Base pairing mode

KW - DNA

KW - NMR

KW - T·T mismatch

UR - http://www.scopus.com/inward/record.url?scp=82555186948&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-82555186948&origin=recordpage

U2 - 10.1016/j.febslet.2011.10.044

DO - 10.1016/j.febslet.2011.10.044

M3 - RGC 21 - Publication in refereed journal

C2 - 22101148

SN - 0014-5793

VL - 585

SP - 3953

EP - 3958

JO - FEBS Letters

JF - FEBS Letters

IS - 24

ER -

Preferential base pairing modes of T·T mismatches

Abstract

Research Keywords

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