Prediction of quaternary assembly of SARS coronavirus peplomer

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

19 Scopus Citations
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Author(s)

  • Andrea Bernini
  • Ottavia Spiga
  • Arianna Ciutti
  • Stefano Chiellini
  • Luisa Bracci
  • Xiyun Yan
  • Bojian Zheng
  • Jiandong Huang
  • Huai-Dong Song
  • Pei Hao
  • Guoping Zhao
  • Neri Niccolai

Detail(s)

Original languageEnglish
Pages (from-to)1210-1214
Journal / PublicationBiochemical and Biophysical Research Communications
Volume325
Issue number4
Publication statusPublished - 24 Dec 2004
Externally publishedYes

Abstract

The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections. © 2004 Elsevier Inc. All rights reserved.

Research Area(s)

  • Quaternary structure prediction, SARS coronavirus, Spike glycoprotein

Citation Format(s)

Prediction of quaternary assembly of SARS coronavirus peplomer. / Bernini, Andrea; Spiga, Ottavia; Ciutti, Arianna et al.
In: Biochemical and Biophysical Research Communications, Vol. 325, No. 4, 24.12.2004, p. 1210-1214.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review