Prediction of quaternary assembly of SARS coronavirus peplomer
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 1210-1214 |
Journal / Publication | Biochemical and Biophysical Research Communications |
Volume | 325 |
Issue number | 4 |
Publication status | Published - 24 Dec 2004 |
Externally published | Yes |
Link(s)
Abstract
The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections. © 2004 Elsevier Inc. All rights reserved.
Research Area(s)
- Quaternary structure prediction, SARS coronavirus, Spike glycoprotein
Citation Format(s)
Prediction of quaternary assembly of SARS coronavirus peplomer. / Bernini, Andrea; Spiga, Ottavia; Ciutti, Arianna et al.
In: Biochemical and Biophysical Research Communications, Vol. 325, No. 4, 24.12.2004, p. 1210-1214.
In: Biochemical and Biophysical Research Communications, Vol. 325, No. 4, 24.12.2004, p. 1210-1214.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review