Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)Not applicablepeer-review

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Author(s)

Detail(s)

Original languageEnglish
Title of host publicationProceedings of the International MultiConference of Engineers and Computer Scientists 2016
PublisherNewswood Limited
Pages942-946
Volume2
ISBN (Print)978-988-14047-6-3
Publication statusPublished - Mar 2016

Conference

TitleInternational Multiconference of Engineers and Computer Scientists 2016, IMECS 2016
PlaceHong Kong
CityTsimshatsui, Kowloon
Period16 - 18 March 2016

Abstract

This paper employs the gradient theory to study the elastic properties and deformability of red blood cell (RBC) membrane using the first-order Cauchy-Born rule as an atomistic-continuum hyperelastic constitutive model that directly incorporates the microstructure of the spectrin network. The well-known Cauchy-Born rule is extended to account for a three-dimensional (3D) reference configuration. Using the strain energy density function and the deformation gradient tensor, the elastic properties of the RBC membrane were predicted by minimizing the potential energy in the representative cell. This extended formulation was then coupled with the meshfree method for numerical modeling of the finite deformation of the RBC membrane by simulating the optical tweezer experiment using a self-written MATLAB code. The results obtained provide new insight into the elastic properties and deformability of RBC membrane. In addition, the proposed method performs better when compared with those found in literature in terms of prediction accuracy and computation efficiency.

Research Area(s)

  • Cauchy-Born rule, Elastic properties, Finite deformation, Meshfree method, Optical tweezers experiment, Red blood cells

Citation Format(s)

Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach. / Ademiloye, A S; Zhang, L W; Liew, K M.

Proceedings of the International MultiConference of Engineers and Computer Scientists 2016. Vol. 2 Newswood Limited, 2016. p. 942-946.

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)Not applicablepeer-review