Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Zhengjie Lin
  • Jun Wu
  • Wei Qiao
  • Ying Zhao
  • Karen H.M. Wong
  • Liming Bian
  • Shuilin Wu
  • Yufeng Zheng
  • Kenneth M.C. Cheung
  • Frankie Leung
  • Kelvin W.K. Yeung

Detail(s)

Original languageEnglish
Journal / PublicationBiomaterials
Volume174
Online published8 May 2018
Publication statusPublished - Aug 2018

Abstract

A range of magnesium ions (Mg2+) used has demonstrated osteogenic tendency in vitro. Hence, we propose to actualize this concept by designing a new system to precisely control the Mg2+ delivery at a particular concentration in vivo in order to effectively stimulate in-situ bone regeneration. To achieve this objective, a monodisperse core-shell microsphere delivery system comprising of poly (lactic-co-glycolic acid) (PLGA) biopolymer, alginate hydrogel, and magnesium oxide nano-particles has been designed by using customized microfluidic capillary device. The PLGA-MgO sponge-like spherical core works as a reservoir of Mg2+ while the alginate shell serves as physical barrier to control the outflow of Mg2+ at ∼50 ppm accurately for 2 weeks via its adjustable surface micro-porous network. With the aid of controlled release of Mg2+, the new core-shell microsphere system can effectively enhance osteoblastic activity in vitro and stimulate in-situ bone regeneration in vivo in terms of total bone volume, bone mineral density (BMD), and trabecular thickness after operation. Interestingly, the Young's moduli of formed bone on the core-shell microsphere group have been restored to ∼96% of that of the surrounding matured bone. These findings indicate that the concept of precisely controlled release of Mg2+ may potentially apply for in-situ bone regeneration clinically.

Research Area(s)

  • Biocompatibility, Bone regeneration, Core-shell microspheres, Microfluidic capillary device, Precisely controlled magnesium ion release

Citation Format(s)

Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration. / Lin, Zhengjie; Wu, Jun; Qiao, Wei; Zhao, Ying; Wong, Karen H.M.; Chu, Paul K.; Bian, Liming; Wu, Shuilin; Zheng, Yufeng; Cheung, Kenneth M.C.; Leung, Frankie; Yeung, Kelvin W.K.

In: Biomaterials, Vol. 174, 08.2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal