Powerful Synergy of Traditional Chinese Medicine and Aggregation-Induced Emission-Active Photosensitizer in Photodynamic Therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Feiyi Sun
  • Hanchen Shen
  • Qingqing Liu
  • Yuyang Chen
  • Wutong Du
  • Changhuo Xu
  • Bingzhe Wang
  • Guichuan Xing
  • Zhuwei Jin
  • Jacky W. Y. Lam
  • Jianwei Sun
  • Ryan T. K. Kwok
  • Jianping Chen
  • Ben Zhong Tang

Detail(s)

Original languageEnglish
Pages (from-to)18952-18964
Journal / PublicationACS Nano
Volume17
Issue number19
Online published20 Sept 2023
Publication statusPublished - 10 Oct 2023

Abstract

Breast cancer (BC) remains a significant global health challenge for women despite advancements in early detection and treatment. Isoliquiritigenin (ISL), a compound derived from traditional Chinese medicine, has shown potential as an anti-BC therapy, but its low bioavailability and poor water solubility restrict its effectiveness. In this study, we created theranostic nanoparticles consisting of ISL and a near-infrared (NIR) photosensitizer, TBPI, which displays aggregation-induced emission (AIE), with the goal of providing combined chemo- and photodynamic therapies (PDT) for BC. Initially, we designed an asymmetric organic molecule, TBPI, featuring a rotorlike triphenylamine as the donor and 1-methylpyridinium iodide as the acceptor, which led to the production of reactive oxygen species in mitochondria. We then combined TBPI with ISL and encapsulated them in DSPE-PEG-RGD nanoparticles to produce IT-PEG-RGD nanoparticles, which showed high affinity for BC, better intersystem crossing (ISC) efficiency, and Förster resonance energy transfer (FRET) between TBPI and ISL. In both 4T1 BC cell line and a 4T1 tumor-bearing BC mouse model, the IT-PEG-RGD nanoparticles demonstrated excellent drug delivery, synergistic antitumor effects, enhanced tumor-killing efficacy, and reduced drug dosage and side effects. Furthermore, we exploited the optical properties of TBPI with ISL to reveal the release process and distribution of nanoparticles in cells. This study provides a valuable basis for further exploration of IT-PEG-RGD nanoparticles and their anticancer mechanisms, highlighting the potential of theranostic nanoparticles in BC treatment. © 2023 American Chemical Society.

Research Area(s)

  • aggregation-induced emission, Förster resonance energy transfer, isoliquiritigenin, photodynamic therapy, traditional Chinese medicine

Citation Format(s)

Powerful Synergy of Traditional Chinese Medicine and Aggregation-Induced Emission-Active Photosensitizer in Photodynamic Therapy. / Sun, Feiyi; Shen, Hanchen; Liu, Qingqing et al.
In: ACS Nano, Vol. 17, No. 19, 10.10.2023, p. 18952-18964.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review