Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Yingjun Wang; Xuetao Shi; Li Ren; Chunming Wang; Dong-An Wang

doi:10.1016/j.msec.2009.07.018

Author(s)

Yingjun Wang
Xuetao Shi
Li Ren
Chunming Wang
Dong-An Wang

Detail(s)

Original language	English
Pages (from-to)	2502-2507
Journal / Publication	Materials Science and Engineering C
Volume	29
Issue number	8
Publication status	Published - 15 Oct 2009
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.msec.2009.07.018 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-72049103165&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(417f7cb9-130f-44bf-a758-0d7f50333d7a).html

Abstract

In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications. © 2009 Elsevier B.V. All rights reserved.

Research Area(s)

Microsphere, Poly (lactic-co-glycolide), Porous, Scaffold

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Citation Format(s)

[ RIS ] [ BibTeX ]

Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications. / Wang, Yingjun; Shi, Xuetao; Ren, Li et al.
In: Materials Science and Engineering C, Vol. 29, No. 8, 15.10.2009, p. 2502-2507.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Wang, Y, Shi, X, Ren, L, Wang, C & Wang, D-A 2009, 'Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications', Materials Science and Engineering C, vol. 29, no. 8, pp. 2502-2507. https://doi.org/10.1016/j.msec.2009.07.018

Wang, Y., Shi, X., Ren, L., Wang, C., & Wang, D.-A. (2009). Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications. Materials Science and Engineering C, 29(8), 2502-2507. https://doi.org/10.1016/j.msec.2009.07.018

Wang Y, Shi X, Ren L, Wang C, Wang DA. Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications. Materials Science and Engineering C. 2009 Oct 15;29(8):2502-2507. doi: 10.1016/j.msec.2009.07.018

Wang, Yingjun ; Shi, Xuetao ; Ren, Li et al. / Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications. In: Materials Science and Engineering C. 2009 ; Vol. 29, No. 8. pp. 2502-2507.