Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)2502-2507
Journal / PublicationMaterials Science and Engineering C
Volume29
Issue number8
Publication statusPublished - 15 Oct 2009
Externally publishedYes

Abstract

In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications. © 2009 Elsevier B.V. All rights reserved.

Research Area(s)

  • Microsphere, Poly (lactic-co-glycolide), Porous, Scaffold

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications. / Wang, Yingjun; Shi, Xuetao; Ren, Li et al.
In: Materials Science and Engineering C, Vol. 29, No. 8, 15.10.2009, p. 2502-2507.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review