Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine

Ye Liu; Yekkuni L Balachandran; Dan Li; Yiming Shao; Xingyu Jiang

doi:10.1021/acsnano.5b08025

Author(s)

Ye Liu
Yekkuni L Balachandran
Dan Li
Yiming Shao
Xingyu Jiang

Detail(s)

Original language	English
Pages (from-to)	3589-3596
Journal / Publication	ACS Nano
Volume	10
Issue number	3
Publication status	Published - 22 Mar 2016
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1021/acsnano.5b08025 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84961964296&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(ed0d4865-a074-4baf-95ee-c726926d06ec).html

Abstract

One of the biggest obstacles for the development of HIV vaccines is how to sufficiently trigger crucial anti-HIV immunities via a safe manner. We herein integrated surface modification-dependent immunostimulation against HIV vaccine and shape-dependent biosafety and designed a safe noncarrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Such silver nanorods can significantly elevate crucial immunities of HIV vaccine and overcome the toxicity, which is a big problem for other existing adjuvants. This study thus provided a principle for designing a safe and high-efficacy material for an adjuvant and allow researchers to really have a safe and effective prophylaxis against HIV. We expect this material approach to be applicable to other types of vaccines, whether they are preventative or therapeutic. © 2016 American Chemical Society.

Research Area(s)

HIV vaccine, immune response, noncarrier adjuvant, poly(ethylene glycol), polyvinylpyrrolidone, silver nanorod

SDG 3 - Good Health and Well-being

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Citation Format(s)

[ RIS ] [ BibTeX ]

Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine. / Liu, Ye; Balachandran, Yekkuni L; Li, Dan et al.
In: ACS Nano, Vol. 10, No. 3, 22.03.2016, p. 3589-3596.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Liu, Y, Balachandran, YL, Li, D, Shao, Y & Jiang, X 2016, 'Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine', ACS Nano, vol. 10, no. 3, pp. 3589-3596. https://doi.org/10.1021/acsnano.5b08025

Liu, Y., Balachandran, Y. L., Li, D., Shao, Y., & Jiang, X. (2016). Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine. ACS Nano, 10(3), 3589-3596. https://doi.org/10.1021/acsnano.5b08025

Liu Y, Balachandran YL, Li D, Shao Y, Jiang X. Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine. ACS Nano. 2016 Mar 22;10(3):3589-3596. doi: 10.1021/acsnano.5b08025

Liu, Ye ; Balachandran, Yekkuni L ; Li, Dan et al. / Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine. In: ACS Nano. 2016 ; Vol. 10, No. 3. pp. 3589-3596.