TY - CHAP
T1 - Polyhydroxyalkanoates and their potential in controlled-release drug delivery systems
T2 - Biomedical applications and factors affecting the drug release
AU - Caon, Thiago
AU - Berezina, Nathalie
AU - Lin, Carol Sze Ki
AU - Fakhouri, Farayde Matta
AU - Martelli, Silvia Maria
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Controlled-release systems have shown several additional advantages over conventional dosage forms, since they are able to improve the temporal and spatial distribution of drugs in the body, reducing the drug degradation under specific physiological conditions and also to improve patient compliance. Due to the high degree of polymerization, biodegradability and biocompatibility characteristics, highly crystalline structure and water insolubility, polyhydroxyalkanoates (PHAs) have received special attention as biomaterials for the preparation of controlled release systems. Depending on the application requirements, different PHAs can be either blended, or have their surfaces modified or combined with other polymers, enzymes or even inorganic materials in order to further improve their mechanical properties or biocompatibility. In this sense, this chapter emphasizes the main physico-chemical processes influencing the drug release rate form controlled release systems so that formulations can be more easily optimized to the intended application, and chemical modifications from polymers may be purposed efficiently.
AB - Controlled-release systems have shown several additional advantages over conventional dosage forms, since they are able to improve the temporal and spatial distribution of drugs in the body, reducing the drug degradation under specific physiological conditions and also to improve patient compliance. Due to the high degree of polymerization, biodegradability and biocompatibility characteristics, highly crystalline structure and water insolubility, polyhydroxyalkanoates (PHAs) have received special attention as biomaterials for the preparation of controlled release systems. Depending on the application requirements, different PHAs can be either blended, or have their surfaces modified or combined with other polymers, enzymes or even inorganic materials in order to further improve their mechanical properties or biocompatibility. In this sense, this chapter emphasizes the main physico-chemical processes influencing the drug release rate form controlled release systems so that formulations can be more easily optimized to the intended application, and chemical modifications from polymers may be purposed efficiently.
KW - Drug delivery
KW - PHAs
KW - Physico-chemical properties
UR - http://www.scopus.com/inward/record.url?scp=84952845792&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84952845792&origin=recordpage
M3 - RGC 12 - Chapter in an edited book (Author)
SN - 9781633216594
SN - 9781633216228
SP - 219
EP - 236
BT - Polyhydroxyalkanoates (PHAs): Biosynthesis, Industrial Production and Applications in Medicine
PB - Nova Science Publishers
ER -