Polyethylenimine-Modified Graphene Oxide as a Novel Antibacterial Agent and Its Synergistic Effect with Daptomycin for Methicillin-Resistant Staphylococcus aureus

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

16 Scopus Citations
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Author(s)

  • Zetan Fan
  • Kathy Hiu Laam Po
  • Ka Kit Wong
  • Sheng Chen
  • Shu Ping Lau

Detail(s)

Original languageEnglish
Pages (from-to)1811-1818
Journal / PublicationACS Applied Nano Materials
Volume1
Issue number4
Online published9 Apr 2018
Publication statusPublished - 27 Apr 2018
Externally publishedYes

Abstract

An aqueous dispersion of polyethylenimine-modified graphene oxide (PEI-GO) was prepared via a one-step synthesis through an epoxy ring opening reaction. PEI-GO exhibited bacterial growth inhibition activity on methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration as low as 8 mu g mL(-1). Time-kill curve assay and SYTOX Green assay showed the antibacterial activity and bacteria cell membrane permeability of PEI-GO, respectively. Most importantly, when PEI-GO was employed at 1-2 mu g mL(-1), a synergistic effect with daptomycin to resensitize daptomycin-resistant MRSA was revealed. A synergistic effect between PEI-GO and daptomycin provides a possible way to increase bacterial killing and reduce the development of daptomycin resistance. The antibacterial activity of PEI-GO is attributed to the damaged cell membrane caused by the sharp edge and chain structure of the PEI-GO nanosheets as well as the high density of amine groups present in the PEI chains. Our results indicate that PEI-GO dispersion has a treatment.

Research Area(s)

  • graphene oxide, polyethylenimine, antibacterial, synergistic effect, methicillin-resistant Staphylococcus aureus, IN-VITRO ACTIVITIES, OUTER-MEMBRANE, SUSCEPTIBILITY, COMBINATIONS, PATHOGENS, POLYMERS, BACTERIA, EXHIBIT, SURFACE

Citation Format(s)

Polyethylenimine-Modified Graphene Oxide as a Novel Antibacterial Agent and Its Synergistic Effect with Daptomycin for Methicillin-Resistant Staphylococcus aureus. / Fan, Zetan; Po, Kathy Hiu Laam; Wong, Ka Kit; Chen, Sheng; Lau, Shu Ping.

In: ACS Applied Nano Materials, Vol. 1, No. 4, 27.04.2018, p. 1811-1818.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review