Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Youxing Cheng
  • Shupeng Zhang
  • Ning Kang
  • Xiaolin Lv
  • Kai Wen
  • Shefang Ye
  • Zhiwei Chen
  • Xi Zhou
  • Lei Ren

Detail(s)

Original languageEnglish
Pages (from-to)19296-19306
Journal / PublicationACS Applied Materials and Interfaces
Volume9
Issue number22
Publication statusPublished - 7 Jun 2017
Externally publishedYes

Abstract

This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region. By synthesizing multifunctional MnCO3@PDA NPs, for example, we found that the longitudinal relaxivity (r1) of MnCO3 NPs can improve from 5.7 to 8.3 mM-1 s-1. Subsequently, in vitro MRI and PTT results verified that MnCO3@PDA could serve as an excellent MRI/PTT theranostic agent. Furthermore, the MnCO3@PDA NPs were applied as an MRI/PTT theranostic agent for in vivo MRI-guided photothermal ablation of tumors by intratumoral injection in 4T1 tumor-bearing mice. The MR imaging result shows a significantly bright MR image in the tumor site. The MnCO3@PDA-mediated PTT result shows high therapeutic efficiency as a result of high photothermal conversion efficiency. The present strategy of amplified MRI-guided PTT based on PDA coating of NPs will be widely applicable to other multifunctional NPs.

Research Area(s)

  • magnetic resonance imaging, Manganese carbonate, multifunctional, photothermal therapy, polydopamine

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy. / Cheng, Youxing; Zhang, Shupeng; Kang, Ning et al.
In: ACS Applied Materials and Interfaces, Vol. 9, No. 22, 07.06.2017, p. 19296-19306.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review