Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy

Youxing Cheng; Shupeng Zhang; Ning Kang; Jianpan Huang; Xiaolin Lv; Kai Wen; Shefang Ye; Zhiwei Chen; Xi Zhou; Lei Ren

doi:10.1021/acsami.7b03087

Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy

Youxing Cheng
, Shupeng Zhang
, Ning Kang
, Jianpan Huang
, Xiaolin Lv
, Kai Wen
, Shefang Ye
, Zhiwei Chen^*
, Xi Zhou
, Lei Ren

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

109 Citations (Scopus)

Abstract

This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region. By synthesizing multifunctional MnCO₃@PDA NPs, for example, we found that the longitudinal relaxivity (r₁) of MnCO₃ NPs can improve from 5.7 to 8.3 mM^-1 s^-1. Subsequently, in vitro MRI and PTT results verified that MnCO₃@PDA could serve as an excellent MRI/PTT theranostic agent. Furthermore, the MnCO₃@PDA NPs were applied as an MRI/PTT theranostic agent for in vivo MRI-guided photothermal ablation of tumors by intratumoral injection in 4T1 tumor-bearing mice. The MR imaging result shows a significantly bright MR image in the tumor site. The MnCO₃@PDA-mediated PTT result shows high therapeutic efficiency as a result of high photothermal conversion efficiency. The present strategy of amplified MRI-guided PTT based on PDA coating of NPs will be widely applicable to other multifunctional NPs.

Original language	English
Pages (from-to)	19296-19306
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	22
DOIs	https://doi.org/10.1021/acsami.7b03087
Publication status	Published - 7 Jun 2017
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This study was financially supported by the National Natural Science Foundation of China (31271071, 31371012, and U1505228).

Research Keywords

magnetic resonance imaging
Manganese carbonate
multifunctional
photothermal therapy
polydopamine

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10.1021/acsami.7b03087

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@article{8dff4dec9ee74770b547a67832af68c6,

title = "Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy",

abstract = "This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region. By synthesizing multifunctional MnCO3@PDA NPs, for example, we found that the longitudinal relaxivity (r1) of MnCO3 NPs can improve from 5.7 to 8.3 mM-1 s-1. Subsequently, in vitro MRI and PTT results verified that MnCO3@PDA could serve as an excellent MRI/PTT theranostic agent. Furthermore, the MnCO3@PDA NPs were applied as an MRI/PTT theranostic agent for in vivo MRI-guided photothermal ablation of tumors by intratumoral injection in 4T1 tumor-bearing mice. The MR imaging result shows a significantly bright MR image in the tumor site. The MnCO3@PDA-mediated PTT result shows high therapeutic efficiency as a result of high photothermal conversion efficiency. The present strategy of amplified MRI-guided PTT based on PDA coating of NPs will be widely applicable to other multifunctional NPs.",

keywords = "magnetic resonance imaging, Manganese carbonate, multifunctional, photothermal therapy, polydopamine",

author = "Youxing Cheng and Shupeng Zhang and Ning Kang and Jianpan Huang and Xiaolin Lv and Kai Wen and Shefang Ye and Zhiwei Chen and Xi Zhou and Lei Ren",

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Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy. / Cheng, Youxing; Zhang, Shupeng; Kang, Ning et al.
In: ACS Applied Materials and Interfaces, Vol. 9, No. 22, 07.06.2017, p. 19296-19306.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy

AU - Cheng, Youxing

AU - Zhang, Shupeng

AU - Kang, Ning

AU - Huang, Jianpan

AU - Lv, Xiaolin

AU - Wen, Kai

AU - Ye, Shefang

AU - Chen, Zhiwei

AU - Zhou, Xi

AU - Ren, Lei

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2017/6/7

Y1 - 2017/6/7

N2 - This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region. By synthesizing multifunctional MnCO3@PDA NPs, for example, we found that the longitudinal relaxivity (r1) of MnCO3 NPs can improve from 5.7 to 8.3 mM-1 s-1. Subsequently, in vitro MRI and PTT results verified that MnCO3@PDA could serve as an excellent MRI/PTT theranostic agent. Furthermore, the MnCO3@PDA NPs were applied as an MRI/PTT theranostic agent for in vivo MRI-guided photothermal ablation of tumors by intratumoral injection in 4T1 tumor-bearing mice. The MR imaging result shows a significantly bright MR image in the tumor site. The MnCO3@PDA-mediated PTT result shows high therapeutic efficiency as a result of high photothermal conversion efficiency. The present strategy of amplified MRI-guided PTT based on PDA coating of NPs will be widely applicable to other multifunctional NPs.

AB - This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region. By synthesizing multifunctional MnCO3@PDA NPs, for example, we found that the longitudinal relaxivity (r1) of MnCO3 NPs can improve from 5.7 to 8.3 mM-1 s-1. Subsequently, in vitro MRI and PTT results verified that MnCO3@PDA could serve as an excellent MRI/PTT theranostic agent. Furthermore, the MnCO3@PDA NPs were applied as an MRI/PTT theranostic agent for in vivo MRI-guided photothermal ablation of tumors by intratumoral injection in 4T1 tumor-bearing mice. The MR imaging result shows a significantly bright MR image in the tumor site. The MnCO3@PDA-mediated PTT result shows high therapeutic efficiency as a result of high photothermal conversion efficiency. The present strategy of amplified MRI-guided PTT based on PDA coating of NPs will be widely applicable to other multifunctional NPs.

KW - magnetic resonance imaging

KW - Manganese carbonate

KW - multifunctional

KW - photothermal therapy

KW - polydopamine

UR - https://www.scopus.com/pages/publications/85020301089

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U2 - 10.1021/acsami.7b03087

DO - 10.1021/acsami.7b03087

M3 - RGC 21 - Publication in refereed journal

C2 - 28508635

SN - 1944-8244

VL - 9

SP - 19296

EP - 19306

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 22

ER -

Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy

Abstract

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Funding

Research Keywords

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