PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Anthony J. Hannan
  • Alla Katsnelson
  • Tania Vitalis
  • Kimberly M. Huber
  • Mark Bear
  • John Roder
  • Daesoo Kim
  • Hee-Sup Shin
  • Peter C. Kind

Detail(s)

Original languageEnglish
Pages (from-to)282-288
Journal / PublicationNature Neuroscience
Volume4
Issue number3
Publication statusPublished - Mar 2001
Externally publishedYes

Abstract

During development of the cerebral cortex, the invasion of thalamic axons and subsequent differentiation of cortical neurons are tightly coordinated. Here we provide evidence that glutamate neurotransmission triggers a critical signaling mechanism involving the activation of phospholipase C-β1 (PLC-β1) by metabotropic glutamate receptors (mGluRs). Homozygous null mutation of either PLC-β1 or mGluR5 dramatically disrupts the cytoarchitectural differentiation of 'barrels' in the mouse somatosensory cortex, despite segregation in the pattern of thalamic innervation. Furthermore, group 1 mGluR-stimulated phosphoinositide hydrolysis is dramatically reduced in PLC-β1-/- mice during barrel development. Our data indicate that PLC-β1 activation via mGluR5 is critical for the coordinated development of the neocortex, and that presynaptic and postsynaptic components of cortical differentiation can be genetically dissociated.

Bibliographic Note

Publication information for this record has been verified with the author(s) concerned

Citation Format(s)

PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. / Hannan, Anthony J.; Blakemore, Colin; Katsnelson, Alla; Vitalis, Tania; Huber, Kimberly M.; Bear, Mark; Roder, John; Kim, Daesoo; Shin, Hee-Sup; Kind, Peter C.

In: Nature Neuroscience, Vol. 4, No. 3, 03.2001, p. 282-288.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal