Platinum anticancer drugs : Targeting and delivery

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 12 - Chapter in an edited book (Author)peer-review

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Detail(s)

Original languageEnglish
Title of host publicationComprehensive Inorganic Chemistry III
EditorsJan Reedijk, Kenneth R. Poeppelmeier, Vincent L. Pecoraro, Zijian Guo
PublisherElsevier
Pages808-846
Volume2
ISBN (Electronic)9780128231531
ISBN (Print)9780128231449
Publication statusPublished - 2023

Abstract

The emergence of platinum drugs has significantly increased the survival rates of cancer patients. The therapeutic outcomes of platinum drugs, however, are still limited by serious side effects that arise from the poor selectivity between cancer and normal cells as well as resistance from cancer cells. Improving the tumor-targeting ability and achieving the targeted delivery of platinum drugs in vivo have been regarded as promising strategies to overcome these limitations. In this chapter, we summarize the strategies for the development of targeted platinum anticancer complexes and delivery systems for carrying platinum complexes to the tumor region, with a focus on their targeting property, antitumor activity, and other advantages over conventional platinum drugs. In addition, we discuss the strengths and challenges of current strategies and proposed perspectives for further development. In summary, this chapter may bring researchers new ideas and help them to design next-generation platinum anticancer complexes. © 2023 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Anticancer drug, Nanodelivery system, Organelle targeting, Platinum drug, Tumor targeting

Citation Format(s)

Platinum anticancer drugs: Targeting and delivery. / Deng, Zhiqin; Yao, Houzong; Wang, Zhigang et al.
Comprehensive Inorganic Chemistry III. ed. / Jan Reedijk; Kenneth R. Poeppelmeier; Vincent L. Pecoraro; Zijian Guo. Vol. 2 Elsevier, 2023. p. 808-846 2.25.

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 12 - Chapter in an edited book (Author)peer-review