Platinated porphyrin as a new organelle and nucleus dual-targeted photosensitizer for photodynamic therapy

Sizhe Zhu; Si Yao; Fengshou Wu; Lijun Jiang; Ka-Leung Wong; Ji Zhou; Kai Wang

doi:10.1039/c7ob01003f

Platinated porphyrin as a new organelle and nucleus dual-targeted photosensitizer for photodynamic therapy

Sizhe Zhu
, Si Yao
, Fengshou Wu
, Lijun Jiang
, Ka-Leung Wong
, Ji Zhou
, Kai Wang

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

50 Citations (Scopus)

Abstract

Organelle and nucleus dual-targeted anticancer drugs are being increasingly used for efficient cancer therapy as they can attack the double vital sites of tumor cells. In this work, we synthesized and characterized two new porphyrin compounds Pt-Por-RB and Me-Por-RB. The spectral titration results suggest that both Pt-Por-RB and Me-Por-RB bind to DNA efficiently in an intercalation binding mode. Upon irradiation, Pt-Por-RB with low dark-cytotoxicity can rapidly generate singlet oxygen to damage the tumor cells through the process of photodynamic therapy. Compared with Me-Por-RB, Pt-Por-RB was not only internalized in the organelles, but also in the nuclei of HeLa cells, probably due to the presence of platinum complexes, as analyzed using the confocal laser scanning microscope. Thus, with the combination of organelle and nucleus dual-targeting property and high efficiency of singlet oxygen generation, Pt-Por-RB showed a significant therapeutic activity against tumor cells. © 2017 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	5764-5771
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	27
DOIs	https://doi.org/10.1039/c7ob01003f
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

The authors are grateful for the financial support of the National Natural Science Foundation of China (grant no. 21601142, 20902071), the Scientific Research Project of Hubei Provincial Department of Education (grant no. Q20161507), the Wuhan Science and Technology Talent Training Program of Chenguang Project (grant no.2015070404010190), the Key Project of Scientific Research Project of Hubei Provincial Department of Education (grant no. D20141506) and the Wuhan Institute of Technology postgraduate students' short-term study abroad (overseas) special funding

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "Platinated porphyrin as a new organelle and nucleus dual-targeted photosensitizer for photodynamic therapy",

abstract = "Organelle and nucleus dual-targeted anticancer drugs are being increasingly used for efficient cancer therapy as they can attack the double vital sites of tumor cells. In this work, we synthesized and characterized two new porphyrin compounds Pt-Por-RB and Me-Por-RB. The spectral titration results suggest that both Pt-Por-RB and Me-Por-RB bind to DNA efficiently in an intercalation binding mode. Upon irradiation, Pt-Por-RB with low dark-cytotoxicity can rapidly generate singlet oxygen to damage the tumor cells through the process of photodynamic therapy. Compared with Me-Por-RB, Pt-Por-RB was not only internalized in the organelles, but also in the nuclei of HeLa cells, probably due to the presence of platinum complexes, as analyzed using the confocal laser scanning microscope. Thus, with the combination of organelle and nucleus dual-targeting property and high efficiency of singlet oxygen generation, Pt-Por-RB showed a significant therapeutic activity against tumor cells. {\textcopyright} 2017 The Royal Society of Chemistry.",

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TY - JOUR

T1 - Platinated porphyrin as a new organelle and nucleus dual-targeted photosensitizer for photodynamic therapy

AU - Zhu, Sizhe

AU - Yao, Si

AU - Wu, Fengshou

AU - Jiang, Lijun

AU - Wong, Ka-Leung

AU - Zhou, Ji

AU - Wang, Kai

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2017

Y1 - 2017

N2 - Organelle and nucleus dual-targeted anticancer drugs are being increasingly used for efficient cancer therapy as they can attack the double vital sites of tumor cells. In this work, we synthesized and characterized two new porphyrin compounds Pt-Por-RB and Me-Por-RB. The spectral titration results suggest that both Pt-Por-RB and Me-Por-RB bind to DNA efficiently in an intercalation binding mode. Upon irradiation, Pt-Por-RB with low dark-cytotoxicity can rapidly generate singlet oxygen to damage the tumor cells through the process of photodynamic therapy. Compared with Me-Por-RB, Pt-Por-RB was not only internalized in the organelles, but also in the nuclei of HeLa cells, probably due to the presence of platinum complexes, as analyzed using the confocal laser scanning microscope. Thus, with the combination of organelle and nucleus dual-targeting property and high efficiency of singlet oxygen generation, Pt-Por-RB showed a significant therapeutic activity against tumor cells. © 2017 The Royal Society of Chemistry.

AB - Organelle and nucleus dual-targeted anticancer drugs are being increasingly used for efficient cancer therapy as they can attack the double vital sites of tumor cells. In this work, we synthesized and characterized two new porphyrin compounds Pt-Por-RB and Me-Por-RB. The spectral titration results suggest that both Pt-Por-RB and Me-Por-RB bind to DNA efficiently in an intercalation binding mode. Upon irradiation, Pt-Por-RB with low dark-cytotoxicity can rapidly generate singlet oxygen to damage the tumor cells through the process of photodynamic therapy. Compared with Me-Por-RB, Pt-Por-RB was not only internalized in the organelles, but also in the nuclei of HeLa cells, probably due to the presence of platinum complexes, as analyzed using the confocal laser scanning microscope. Thus, with the combination of organelle and nucleus dual-targeting property and high efficiency of singlet oxygen generation, Pt-Por-RB showed a significant therapeutic activity against tumor cells. © 2017 The Royal Society of Chemistry.

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UR - https://www.scopus.com/pages/publications/85024383245#tab=impact

U2 - 10.1039/c7ob01003f

DO - 10.1039/c7ob01003f

M3 - RGC 21 - Publication in refereed journal

C2 - 28660264

SN - 1477-0520

VL - 15

SP - 5764

EP - 5771

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 27

ER -

Platinated porphyrin as a new organelle and nucleus dual-targeted photosensitizer for photodynamic therapy

Abstract

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