Plasticity of binocularity and visual acuity are differentially limited by nogo receptor

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Céleste-Élise Stephany
  • Sherveen N. Parivash
  • Hilary M. Dorton
  • Mariel Piechowicz
  • Shenfeng Qiu
  • Aaron W. McGee

Detail(s)

Original languageEnglish
Pages (from-to)11631-11640
Journal / PublicationJournal of Neuroscience
Volume34
Issue number35
Publication statusPublished - 27 Aug 2014

Link(s)

Abstract

The closure of developmental critical periods consolidates neural circuitry but also limits recovery from early abnormal sensory experience. Degrading vision by one eye throughout a critical period both perturbs ocular dominance (OD) in primary visual cortex and impairs visual acuity permanently. Yet understanding how binocularity and visual acuity interrelate has proven elusive. Here we demonstrate the plasticity of binocularity and acuity are separable and differentially regulated by the neuronal nogo receptor 1 (NgR1). Mice lacking NgR1 display developmental OD plasticity as adults and their visual acuity spontaneously improves after prolonged monocular deprivation. Restricting deletion of NgR1 to either cortical interneurons or a subclass of parvalbumin (PV)-positive interneurons alters intralaminar synaptic connectivity in visual cortex and prevents closure of the critical period for OD plasticity. However, loss of NgR1 in PV neurons does not rescue deficits in acuity induced by chronic visual deprivation. Thus, NgR1 functions with PV interneurons to limit plasticity of binocularity, but its expression is required more extensively within brain circuitry to limit improvement of visual acuity following chronic deprivation.

Research Area(s)

  • Cre recombinase, Mice, Nogo receptor, Ocular dominance plasticity, Parvalbumin, Visual acuity

Citation Format(s)

Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. / Stephany, Céleste-Élise; Chan, Leanne L.H.; Parivash, Sherveen N.; Dorton, Hilary M.; Piechowicz, Mariel; Qiu, Shenfeng; McGee, Aaron W.

In: Journal of Neuroscience, Vol. 34, No. 35, 27.08.2014, p. 11631-11640.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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