TY - JOUR
T1 - Plasmonic sensors for extracellular vesicle analysis
T2 - From scientific development to translational research
AU - Chin, Lip Ket
AU - Son, Taehwang
AU - Hong, Jae-Sang
AU - Liu, Ai-Qun
AU - Skog, Johan
AU - Castro, Cesar M.
AU - Weissleder, Ralph
AU - Lee, Hakho
AU - Im, Hyungsoon
PY - 2020/11/24
Y1 - 2020/11/24
N2 - Extracellular vesicles (EVs), actively shed from a variety of neoplastic and host cells, are abundant in blood and carry molecular markers from parental cells. For these reasons, EVs have gained much interest as biomarkers of disease. Among a number of different analytical methods that have been developed, surface plasmon resonance (SPR) stands out as one of the ideal techniques given its sensitivity, robustness, and ability to miniaturize. In this Review, we compare different SPR platforms for EV analysis, including conventional SPR, nanoplasmonic sensors, surface-enhanced Raman spectroscopy, and plasmonic-enhanced fluorescence. We discuss different surface chemistries used to capture targeted EVs and molecularly profile their proteins and RNAs. We also highlight these plasmonic platforms' clinical applications, including cancers, neurodegenerative diseases, and cardiovascular diseases. Finally, we discuss the future perspective of plasmonic sensing for EVs and their potentials for commercialization and clinical translation.
AB - Extracellular vesicles (EVs), actively shed from a variety of neoplastic and host cells, are abundant in blood and carry molecular markers from parental cells. For these reasons, EVs have gained much interest as biomarkers of disease. Among a number of different analytical methods that have been developed, surface plasmon resonance (SPR) stands out as one of the ideal techniques given its sensitivity, robustness, and ability to miniaturize. In this Review, we compare different SPR platforms for EV analysis, including conventional SPR, nanoplasmonic sensors, surface-enhanced Raman spectroscopy, and plasmonic-enhanced fluorescence. We discuss different surface chemistries used to capture targeted EVs and molecularly profile their proteins and RNAs. We also highlight these plasmonic platforms' clinical applications, including cancers, neurodegenerative diseases, and cardiovascular diseases. Finally, we discuss the future perspective of plasmonic sensing for EVs and their potentials for commercialization and clinical translation.
KW - Biomarkers
KW - Biosensing
KW - Diagnostics
KW - Extracellular vesicles
KW - Nanoplasmonics
KW - Plasmon-enhanced fluorescence
KW - Surface plasmon resonance
KW - Surface-enhanced Raman spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85096346896&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85096346896&origin=recordpage
U2 - 10.1021/acsnano.0c07581
DO - 10.1021/acsnano.0c07581
M3 - RGC 21 - Publication in refereed journal
C2 - 33119256
SN - 1936-0851
VL - 14
SP - 14528
EP - 14548
JO - ACS Nano
JF - ACS Nano
IS - 11
ER -
