Plasmonic metallic nanoparticle-based biosensors

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

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Detail(s)

Original languageEnglish
Title of host publicationEnhanced Spectroscopies and Nanoimaging 2023
EditorsPrabhat Verma, Yung Doug Suh
PublisherSPIE
ISBN (electronic)9781510665231
ISBN (print)9781510665224
Publication statusPublished - 2023

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume12654
ISSN (Print)0277-786X
ISSN (electronic)1996-756X

Conference

TitleEnhanced Spectroscopies and Nanoimaging 2023
PlaceUnited States
CitySan Diego
Period20 - 23 August 2023

Abstract

Bifunctional nanoparticle of combining magnetic and plasmonic nanomaterials retain both unique properties, contributing to the high photothermal performance, excellent biocompatibility, physiological stability, low cytotoxicity and easy separation. Herein, we report a core-shell plasmonic magnetic nanostructure (PMNs), then introduce the plasmonic photothermal polymerase chain reaction (PPT-PCR) platform for fast, sensitive, cheap, and simple nucleic acid detection based on PMNs. Magnetic nanoparticles can be synthesized by solvothermal reaction. PMNs can be prepared after Au coating on the magnetic core, which can act as nanoheater and heat solution to 95 ℃ in several seconds upon infra-red (IR) light irradiation, and can be collected by magnet easily. Furthermore, our platforms utilize ultrafast PCR amplification based on the photothermal effect of plasmonic magnetic nanoparticles for molecular diagnostics through two modes, including in-situ end-point quantitative fluorescence detection (PPT-qPCR) and colorimetric assay (PPT-cPCR), having comparable limit of detection (LOD) on DNA targets. © 2023 SPIE.

Research Area(s)

  • bifunctional nanoparticle, biosensor, colorimetric, photothermal effect, Plasmonic magnetic nanoparticle, plasmonic PCR, polymerase chain reaction

Bibliographic Note

Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

Citation Format(s)

Plasmonic metallic nanoparticle-based biosensors. / Lee, Jung-hoon; Mi, Hua.
Enhanced Spectroscopies and Nanoimaging 2023. ed. / Prabhat Verma; Yung Doug Suh. SPIE, 2023. 126540B (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 12654).

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review