Plasminogen Activator Inhibitor 1 for Predicting Sepsis Severity and Mortality Outcomes : A Systematic Review and Meta-Analysis

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Timothy L. Tipoe
  • William K. K. Wu
  • Lilianna Chung
  • Mengqi Gong
  • Mei Dong
  • And 8 others
  • Tong Liu
  • Leonardo Roever
  • Jeffery Ho
  • Martin C. S. Wong
  • Matthew T. V. Chan
  • Gary Tse
  • Justin C. Y. Wu
  • Sunny H. Wong

Detail(s)

Original languageEnglish
Article number1218
Number of pages6
Journal / PublicationFrontiers in Immunology
Volume9
Online published18 Jun 2018
Publication statusPublished - Jun 2018
Externally publishedYes

Link(s)

Abstract

Objectives: Plasminogen activator inhibitor-1 (PAI-1), a crucial regulator of fibrinolysis, is increased in sepsis, but its values in predicting disease severity or mortality outcomes have been controversial. Therefore, we conducted a systematic review and meta-analysis of its predictive values in sepsis.

Methods: PubMed and Embase were searched until August 18, 2017 for studies that evaluated the relationships between PAI-1 levels and disease severity or mortality in sepsis.

Results: A total of 112 and 251 entries were retrieved from the databases, of which 18 studies were included in the final meta-analysis. A total of 4,467 patients (36% male, mean age: 62 years, mean follow-up duration: 36 days) were analyzed. PAI-1 levels were significantly higher in non-survivors than survivors [odds ratios (OR): 3.93, 95% confidence interval (CI): 2.31-6.67, P <0.0001] and in patients with severe sepsis than in those less severe sepsis (OR: 3.26, 95% CI: 1.37-7.75, P = 0.008).

Conclusion: PAI-1 is a significant predictor of disease severity and all-cause mortality in sepsis. Although the predictive values of PAI-1 reached statistical significance, the clinical utility of PAI-1 in predicting outcomes will require carefully designed prospective trials.

Research Area(s)

  • plasminogen activator inhibitor-1, sepsis, mortality, meta-analysis, systematic review, DISSEMINATED INTRAVASCULAR COAGULATION, ENDOTHELIAL-CELL ACTIVATION, INTENSIVE-CARE-UNIT, PROTEIN-C ACTIVITY, SEPTIC SHOCK, ORGAN DYSFUNCTION, CRITICALLY-ILL, FIBRINOLYSIS, IDENTIFICATION, POLYMORPHISMS

Citation Format(s)

Plasminogen Activator Inhibitor 1 for Predicting Sepsis Severity and Mortality Outcomes: A Systematic Review and Meta-Analysis. / Tipoe, Timothy L.; Wu, William K. K.; Chung, Lilianna et al.
In: Frontiers in Immunology, Vol. 9, 1218, 06.2018.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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