Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Hao Zhang
  • Shengduo Xu
  • Jishen Zhang
  • Zifeng Wang
  • Dingxin Liu
  • Li Guo
  • Cheng Cheng
  • Yilong Cheng
  • Dehui Xu
  • Michael G. Kong
  • Mingzhe Rong

Detail(s)

Original languageEnglish
Article number121057
Journal / PublicationBiomaterials
Volume276
Online published9 Aug 2021
Publication statusPublished - Sep 2021

Abstract

Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.

Research Area(s)

  • Plasma-activated biogel, Post-operative tumor treatment, Reactive oxygen species, Surface discharge plasma

Citation Format(s)

Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer. / Zhang, Hao; Xu, Shengduo; Zhang, Jishen; Wang, Zifeng; Liu, Dingxin; Guo, Li; Cheng, Cheng; Cheng, Yilong; Xu, Dehui; Kong, Michael G.; Rong, Mingzhe; Chu, Paul K.

In: Biomaterials, Vol. 276, 121057, 09.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review