Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Ying Zhao
  • Hoi Man Wong
  • So Ching Lui
  • Eva Y. W. Chong
  • Guosong Wu
  • Xiaoli Zhao
  • Chong Wang
  • Haobo Pan
  • Kenneth M. C. Cheung
  • Shuilin Wu
  • Kelvin W. K. Yeung

Detail(s)

Original languageEnglish
Pages (from-to)3901-3911
Journal / PublicationACS Applied Materials and Interfaces
Volume8
Issue number6
Online published21 Jan 2016
Publication statusPublished - 17 Feb 2016

Abstract

This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer. © 2016 American Chemical Society.

Research Area(s)

  • interface, osseointegration, plasma immersion ion implantation, polyetheretherketone (PEEK), surface modification

Citation Format(s)

Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface. / Zhao, Ying; Wong, Hoi Man; Lui, So Ching et al.
In: ACS Applied Materials and Interfaces, Vol. 8, No. 6, 17.02.2016, p. 3901-3911.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review