TY - JOUR
T1 - Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface
AU - Zhao, Ying
AU - Wong, Hoi Man
AU - Lui, So Ching
AU - Chong, Eva Y. W.
AU - Wu, Guosong
AU - Zhao, Xiaoli
AU - Wang, Chong
AU - Pan, Haobo
AU - Cheung, Kenneth M. C.
AU - Wu, Shuilin
AU - Chu, Paul K.
AU - Yeung, Kelvin W. K.
PY - 2016/2/17
Y1 - 2016/2/17
N2 - This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer. © 2016 American Chemical Society.
AB - This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer. © 2016 American Chemical Society.
KW - interface
KW - osseointegration
KW - plasma immersion ion implantation
KW - polyetheretherketone (PEEK)
KW - surface modification
UR - http://www.scopus.com/inward/record.url?scp=84959017973&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84959017973&origin=recordpage
U2 - 10.1021/acsami.5b10881
DO - 10.1021/acsami.5b10881
M3 - RGC 21 - Publication in refereed journal
SN - 1944-8244
VL - 8
SP - 3901
EP - 3911
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 6
ER -