Plasma concentrations of buprenorphine after epidural administration in conscious cats

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)480-483
Journal / PublicationResearch in Veterinary Science
Volume90
Issue number3
Publication statusPublished - Jun 2011
Externally publishedYes

Abstract

Buprenorphine plasma concentrations were measured after administering buprenorphine (20 μg/kg) into the lumbosacral epidural space of conscious cats chronically instrumented with an epidural catheter. Blood was collected from a jugular vein before injection and 15, 30, 45 and 60. min and 2, 3, 4, 5, 6, 8, 12 and 24. h after administration. Plasma buprenorphine concentrations were measured using ELISA. Background concentration (before injection) was 1.27 ± 0.27. ng/mL (mean ± SD). Including background concentration, the mean peak plasma concentration was obtained 15. min after injection (5.82 ± 3.75. ng/mL), and ranged from 3.79 to 2.20. ng/mL (30. min-3. h), remaining between 1.93 and 1.77. ng/mL (4-12. h), and declined to 1.40 ± 0.62. ng/mL at 24. h. Elimination half-life was 58.8 ± 40.2. min and clearance 56.7 ± 21.5. mL/min. Results indicate early rapid systemic uptake of buprenorphine from epidural administration with plasma concentrations similar to using buccal or IM routes by 15. min postinjection. © 2010 Elsevier Ltd.

Research Area(s)

  • Buprenorphine, Cat, Epidural, Plasma concentration

Bibliographic Note

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Citation Format(s)

Plasma concentrations of buprenorphine after epidural administration in conscious cats. / Duke-Novakovski, Tanya; Clark, Christopher R.; Ambros, Barbara; Gilbert, Peter; Steagall, Paulo V.M.

In: Research in Veterinary Science, Vol. 90, No. 3, 06.2011, p. 480-483.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review