Plasma concentrations of buprenorphine after epidural administration in conscious cats

Tanya Duke-Novakovski; Christopher R. Clark; Barbara Ambros; Peter Gilbert; Paulo V.M. Steagall

doi:10.1016/j.rvsc.2010.07.010

Plasma concentrations of buprenorphine after epidural administration in conscious cats

Tanya Duke-Novakovski, Christopher R. Clark, Barbara Ambros, Peter Gilbert, Paulo V.M. Steagall

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

Abstract

Buprenorphine plasma concentrations were measured after administering buprenorphine (20 μg/kg) into the lumbosacral epidural space of conscious cats chronically instrumented with an epidural catheter. Blood was collected from a jugular vein before injection and 15, 30, 45 and 60. min and 2, 3, 4, 5, 6, 8, 12 and 24. h after administration. Plasma buprenorphine concentrations were measured using ELISA. Background concentration (before injection) was 1.27 ± 0.27. ng/mL (mean ± SD). Including background concentration, the mean peak plasma concentration was obtained 15. min after injection (5.82 ± 3.75. ng/mL), and ranged from 3.79 to 2.20. ng/mL (30. min-3. h), remaining between 1.93 and 1.77. ng/mL (4-12. h), and declined to 1.40 ± 0.62. ng/mL at 24. h. Elimination half-life was 58.8 ± 40.2. min and clearance 56.7 ± 21.5. mL/min. Results indicate early rapid systemic uptake of buprenorphine from epidural administration with plasma concentrations similar to using buccal or IM routes by 15. min postinjection. © 2010 Elsevier Ltd.

Original language	English
Pages (from-to)	480-483
Journal	Research in Veterinary Science
Volume	90
Issue number	3
DOIs	https://doi.org/10.1016/j.rvsc.2010.07.010
Publication status	Published - Jun 2011
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

Buprenorphine
Cat
Epidural
Plasma concentration

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@article{07d04ed8846942bf8273c91c8ccbeed6,

title = "Plasma concentrations of buprenorphine after epidural administration in conscious cats",

abstract = "Buprenorphine plasma concentrations were measured after administering buprenorphine (20 μg/kg) into the lumbosacral epidural space of conscious cats chronically instrumented with an epidural catheter. Blood was collected from a jugular vein before injection and 15, 30, 45 and 60. min and 2, 3, 4, 5, 6, 8, 12 and 24. h after administration. Plasma buprenorphine concentrations were measured using ELISA. Background concentration (before injection) was 1.27 ± 0.27. ng/mL (mean ± SD). Including background concentration, the mean peak plasma concentration was obtained 15. min after injection (5.82 ± 3.75. ng/mL), and ranged from 3.79 to 2.20. ng/mL (30. min-3. h), remaining between 1.93 and 1.77. ng/mL (4-12. h), and declined to 1.40 ± 0.62. ng/mL at 24. h. Elimination half-life was 58.8 ± 40.2. min and clearance 56.7 ± 21.5. mL/min. Results indicate early rapid systemic uptake of buprenorphine from epidural administration with plasma concentrations similar to using buccal or IM routes by 15. min postinjection. {\textcopyright} 2010 Elsevier Ltd.",

keywords = "Buprenorphine, Cat, Epidural, Plasma concentration",

author = "Tanya Duke-Novakovski and Clark, {Christopher R.} and Barbara Ambros and Peter Gilbert and Steagall, {Paulo V.M.}",

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year = "2011",

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doi = "10.1016/j.rvsc.2010.07.010",

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TY - JOUR

T1 - Plasma concentrations of buprenorphine after epidural administration in conscious cats

AU - Duke-Novakovski, Tanya

AU - Clark, Christopher R.

AU - Ambros, Barbara

AU - Gilbert, Peter

AU - Steagall, Paulo V.M.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2011/6

Y1 - 2011/6

N2 - Buprenorphine plasma concentrations were measured after administering buprenorphine (20 μg/kg) into the lumbosacral epidural space of conscious cats chronically instrumented with an epidural catheter. Blood was collected from a jugular vein before injection and 15, 30, 45 and 60. min and 2, 3, 4, 5, 6, 8, 12 and 24. h after administration. Plasma buprenorphine concentrations were measured using ELISA. Background concentration (before injection) was 1.27 ± 0.27. ng/mL (mean ± SD). Including background concentration, the mean peak plasma concentration was obtained 15. min after injection (5.82 ± 3.75. ng/mL), and ranged from 3.79 to 2.20. ng/mL (30. min-3. h), remaining between 1.93 and 1.77. ng/mL (4-12. h), and declined to 1.40 ± 0.62. ng/mL at 24. h. Elimination half-life was 58.8 ± 40.2. min and clearance 56.7 ± 21.5. mL/min. Results indicate early rapid systemic uptake of buprenorphine from epidural administration with plasma concentrations similar to using buccal or IM routes by 15. min postinjection. © 2010 Elsevier Ltd.

AB - Buprenorphine plasma concentrations were measured after administering buprenorphine (20 μg/kg) into the lumbosacral epidural space of conscious cats chronically instrumented with an epidural catheter. Blood was collected from a jugular vein before injection and 15, 30, 45 and 60. min and 2, 3, 4, 5, 6, 8, 12 and 24. h after administration. Plasma buprenorphine concentrations were measured using ELISA. Background concentration (before injection) was 1.27 ± 0.27. ng/mL (mean ± SD). Including background concentration, the mean peak plasma concentration was obtained 15. min after injection (5.82 ± 3.75. ng/mL), and ranged from 3.79 to 2.20. ng/mL (30. min-3. h), remaining between 1.93 and 1.77. ng/mL (4-12. h), and declined to 1.40 ± 0.62. ng/mL at 24. h. Elimination half-life was 58.8 ± 40.2. min and clearance 56.7 ± 21.5. mL/min. Results indicate early rapid systemic uptake of buprenorphine from epidural administration with plasma concentrations similar to using buccal or IM routes by 15. min postinjection. © 2010 Elsevier Ltd.

KW - Buprenorphine

KW - Cat

KW - Epidural

KW - Plasma concentration

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DO - 10.1016/j.rvsc.2010.07.010

M3 - RGC 21 - Publication in refereed journal

C2 - 20709341

SN - 0034-5288

VL - 90

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EP - 483

JO - Research in Veterinary Science

JF - Research in Veterinary Science

IS - 3

ER -

Plasma concentrations of buprenorphine after epidural administration in conscious cats

Abstract

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