Plasma cholesterol-raising potency of dietary free cholesterol versus cholesteryl ester and effect of β-sitosterol

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Yuwei Liu
  • Lin Lei
  • Xiaobo Wang
  • Ka Ying Ma
  • Yuk Man Li
  • Lijun Wang
  • Sun Wa Man
  • Zhen-Yu Chen

Detail(s)

Original languageEnglish
Pages (from-to)277-282
Journal / PublicationFood Chemistry
Volume169
Publication statusPublished - 15 Feb 2015
Externally publishedYes

Abstract

The present study (i) compared plasma cholesterol-raising activity of free cholesterol (FC) with that of cholesteryl palmitate (CP) and (ii) examined plasma cholesterol-reducing activity of β-sitosterol in FC-induced and CP-induced hypercholesterolemia. Male hamsters were divided into five groups and fed one of the five diets containing no cholesterol (NC), 2.6 mmol cholesterol (C), 2.6 mmol cholesterol plus 2.6 mmol β-sitosterol (C+S), 2.6 mmol cholesteryl palmitate (CP), and 2.6 mmol CP plus 2.6 mmol β-sitosterol (CP+S), respectively, for 8 weeks. Hamsters fed diet C had plasma TC of 317.5 mg/dl whereas hamsters fed diet CP has plasma TC of 281.3 mg/dl. β-Sitosterol reduced plasma TC by 17.4% and 11.6%, respectively, in FC-induced and CP-induced hypercholesterolemia (not significant). It was concluded that plasma cholesterol-raising activity of dietary cholesterol was a function of its chemical forms in diet, and β-sitosterol could similarly suppress the hypercholesterolemia induced by both dietary FC and CP. © 2014 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Cholesterol, Cholesteryl ester, Lipoprotein profile, NPC1L1, β-Sitosterol

Bibliographic Note

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Citation Format(s)

Plasma cholesterol-raising potency of dietary free cholesterol versus cholesteryl ester and effect of β-sitosterol. / Liu, Yuwei; Lei, Lin; Wang, Xiaobo et al.
In: Food Chemistry, Vol. 169, 15.02.2015, p. 277-282.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review