TY - JOUR
T1 - Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer
AU - Zhang, Hao
AU - Xu, Shengduo
AU - Zhang, Jishen
AU - Wang, Zifeng
AU - Liu, Dingxin
AU - Guo, Li
AU - Cheng, Cheng
AU - Cheng, Yilong
AU - Xu, Dehui
AU - Kong, Michael G.
AU - Rong, Mingzhe
AU - Chu, Paul K.
PY - 2021/9
Y1 - 2021/9
N2 - Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.
AB - Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.
KW - Plasma-activated biogel
KW - Post-operative tumor treatment
KW - Reactive oxygen species
KW - Surface discharge plasma
UR - http://www.scopus.com/inward/record.url?scp=85112473643&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85112473643&origin=recordpage
U2 - 10.1016/j.biomaterials.2021.121057
DO - 10.1016/j.biomaterials.2021.121057
M3 - RGC 21 - Publication in refereed journal
SN - 0142-9612
VL - 276
JO - Biomaterials
JF - Biomaterials
M1 - 121057
ER -
