Plant-Derived Single-Molecule-Based Nanotheranostics for Photoenhanced Chemotherapy and Ferroptotic-Like Cancer Cell Death

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

6 Scopus Citations
View graph of relations

Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)2643-2649
Journal / PublicationACS Applied Bio Materials
Volume2
Issue number6
Online published22 May 2019
Publication statusPublished - 17 Jun 2019

Abstract

Although piperine - an extract from pepper - has a mild chemotherapeutic effect, its poor water solubility has limited its applications for cancer therapy. With self-assembling of piperine into nanoparticles along with PEG (Pip NPs), both the water dispersibility and the chemotherapeutic efficacy can be substantially enhanced. It is further shown that the NPs can generate reactive oxygen species (ROS) with or without additional white light irradiation. Interestingly, the Pip NP induced cell death can be suppressed by ferroptosis inhibitors such as liproxstatin-1 and deferoxamine. Lipid ROS production is also observed in Pip NP treated cells. In addition to their cancer cell killing ability, the Pip NPs also show strong green fluorescence. These multiple functions make the Pip NPs a promising and low-cost nanotheranostic agent with herbal origin.

Research Area(s)

  • chemotherapy, ferroptosis, nanodrug, nanotheranostic, plant-derived single molecule

Citation Format(s)

Plant-Derived Single-Molecule-Based Nanotheranostics for Photoenhanced Chemotherapy and Ferroptotic-Like Cancer Cell Death. / Chelora, Jipsa; Zhang, Jinfeng; Wan, Yingpeng; Cui, Xiao; Zhao, Junfang; Meng, Xiang-Min; Wang, Pengfei; Lee, Chun-Sing.

In: ACS Applied Bio Materials, Vol. 2, No. 6, 17.06.2019, p. 2643-2649.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review