Pilot study on evaluation of any correlation between MR perfusion (K trans) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 tesla

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jian-Ping Chu
  • Henry Ka-Fung Mak
  • Linda Zhang
  • Janice Tsang
  • Queenie Chan
  • Gilberto Ka-Kit Leung

Detail(s)

Original languageEnglish
Pages (from-to)1-6
Journal / PublicationCancer Imaging
Volume12
Issue number1
Publication statusPublished - 2012
Externally publishedYes

Abstract

Purpose: To assess any correlation of volume transfer constant (K trans) with apparent diffusion coefficient (ADC) in different brain tumor types at 3 T magnetic resonance (MR) imaging. Materials and methods: Thirteen patients with brain tumors (8 men, 5 women; mean age 54.6 ± 17.7 years) were enrolled in this retrospective study. All patients underwent dynamic contrast-enhanced T 1-weighted MR perfusion and diffusion-weighted imaging using a 3 T scanner. K trans was estimated by specially designed software. For each tumor, regions of interest (ROIs) were manually selected on corresponding K trans and ADC maps. Pearson correlation coefficients were obtained for maximum, mean and minimum values of K trans and ADC of all ROIs. Based on clinicopathologic results, the final diagnoses of patients were glioblastoma multiforme (3), low-grade to anaplastic gliomas (4), meningiomas (3) and metastatic tumors (3). Results: K trans(max) values were significantly inversely correlated with ADC(min) values (r=-0.536, Ptrans(mean) and K trans(min) values were significantly inversely correlated with ADC(mean) (r=-0.228, P=0.038) and ADC(max) values (r=-0.355, P=0.001), respectively. Conclusion: We found that irrespective of brain tumor type, there is an inverse correlation between ADC and K trans. Our findings highlight an intricate relationship between vascular permeability and the tumor microenvironment, probably modulating and/or interacting with changes such as increased cellularity, ischemic insult and varying extracellular matrix composition. © 2012 International Cancer Imaging Society.

Research Area(s)

  • Apparent diffusion coefficient, Blood-brain barrier, Brain tumor, Diffusion-weighted imaging, Dynamic contrast-enhanced MRI, Permeability

Citation Format(s)

Pilot study on evaluation of any correlation between MR perfusion (K trans) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 tesla. / Chu, Jian-Ping; Mak, Henry Ka-Fung; Yau, Kelvin Kai-Wing; Zhang, Linda; Tsang, Janice; Chan, Queenie; Leung, Gilberto Ka-Kit.

In: Cancer Imaging, Vol. 12, No. 1, 2012, p. 1-6.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review