Physical characterization of oleanolic acid nonsolvate and solvates prepared by solvent recrystallization

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Henry H.Y. Tong
  • H. B. Wu
  • Y. Zheng
  • J. Xi
  • Albert H.L. Chow

Detail(s)

Original languageEnglish
Pages (from-to)195-202
Journal / PublicationInternational Journal of Pharmaceutics
Volume355
Issue number1-2
Publication statusPublished - 1 May 2008
Externally publishedYes

Abstract

Oleanolic acid is a naturally occurring compound used clinically in China for the treatment of hepatitis B. The solid-state chemistry of oleanolic acid recrystallized from a variety of solvents was investigated. Glassy materials were prepared from dichloromethane and chloroform solvents. The oleanolic acid non-solvate prepared from acetone (OA-acetone), and the two oleanolic acid solvates prepared from methanol (OA-methanol) and ethanol (OA-ethanol) were physicochemically characterized. Upon desolvation, both the methanol and ethanol solvates were found to undergo phase transformation to a crystalline phase similar to OA-acetone around 190-195 °C. The PXRD patterns of commercial pharmaceutical grade OA and the OA-methanol were similar, so the commercial form is probably desolvated oleanolic acid methanol solvate. © 2007 Elsevier B.V. All rights reserved.

Research Area(s)

  • Oleanolic acid, Solid-state transition, Solvates, Solvent recrystallization

Citation Format(s)

Physical characterization of oleanolic acid nonsolvate and solvates prepared by solvent recrystallization. / Tong, Henry H.Y.; Wu, H. B.; Zheng, Y.; Xi, J.; Chow, Albert H.L.; Chan, Chak K.

In: International Journal of Pharmaceutics, Vol. 355, No. 1-2, 01.05.2008, p. 195-202.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review