PH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

14 Scopus Citations
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Author(s)

  • Hui Li
  • Xiang Zhou
  • Dongbao Yao
  • Haojun Liang

Detail(s)

Original languageEnglish
Pages (from-to)3520-3523
Journal / PublicationChemical Communications
Volume54
Issue number28
Online published8 Mar 2018
Publication statusPublished - 11 Apr 2018

Abstract

Herein, a class of pH-responsive spherical nucleic acid (SNA) nanostructures prepared by functionalizing gold nanoparticles with DNA nanodevices is presented, which can perform duplex-to-triplex transition upon pH change via pH-sensitive parallel Hoogsteen interactions. The SNA nanostructures exhibit tunable pH sensitivity and a highly rapid and reversible allosteric effect. Furthermore, they can exactly image lysosomes in living cells. We next engineered pH-triggered doxorubicin(Dox)-SNA conjugates that could deliver Dox molecules into cancer cells and achieve pH-dependent drug release.