Photothermal bleaching in time-lapse photoacoustic microscopy

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

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Author(s)

  • Liang Gao
  • Lidai Wang
  • Chiye Li
  • Alejandro Garcia-Uribe
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2014
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Print)9780819498564
Publication statusPublished - Feb 2014
Externally publishedYes

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8943
ISSN (Print)1605-7422

Conference

TitlePhotons Plus Ultrasound: Imaging and Sensing 2014
PlaceUnited States
CitySan Francisco
Period2 - 5 February 2014

Abstract

We studied the phenomenon of photothermal bleaching - a gradual reduction of contrast agent particles during repeated scans in photoacoustic microscopy. The dependence of the photothermal bleaching rate on the excitation pulse energy was determined while the laser focal diameter was held constant. Our results showed that, the dependence of the photothermal bleaching rate on the excitation pulse energy differed before and after the absorbers were raised to their melting point by the deposited laser energy. Based on this finding, we suggested an optimal excitation pulse energy, which balances the photothermal bleaching rate and signal amplitude, for time-lapse imaging applications.

Research Area(s)

  • Photoacoustic microscopy, Photothermal bleaching

Citation Format(s)

Photothermal bleaching in time-lapse photoacoustic microscopy. / Gao, Liang; Wang, Lidai; Li, Chiye et al.
Photons Plus Ultrasound: Imaging and Sensing 2014. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2014. 89433G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8943).

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review