Photosensitizers for Photodynamic Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Minhuan Lan
  • Shaojing Zhao
  • Weimin Liu
  • Pengfei Wang

Detail(s)

Original languageEnglish
Article number1900132
Journal / PublicationAdvanced Healthcare Materials
Volume8
Issue number13
Online published8 May 2019
Publication statusPublished - 11 Jul 2019

Abstract

As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O2). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials. The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted. Moreover, the approaches that combine PDT with other therapeutics (e.g., chemotherapy, photothermal therapy, and radiotherapy) and the targeted delivery in cancer cells or tumor tissue are introduced. The main challenges for the clinical application of PSs are also discussed.

Research Area(s)

  • photodynamic therapy, photosensitizers, photothermal therapy

Citation Format(s)

Photosensitizers for Photodynamic Therapy. / Lan, Minhuan; Zhao, Shaojing; Liu, Weimin; Lee, Chun-Sing; Zhang, Wenjun; Wang, Pengfei.

In: Advanced Healthcare Materials, Vol. 8, No. 13, 1900132, 11.07.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review