Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA)

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

6 Scopus Citations
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Author(s)

  • Juan Li
  • Ashna Gopal
  • Sena Karaosmanoglu
  • Jiafu Lin
  • Tasnim Munshi
  • Xianfeng Chen
  • Li Yan

Detail(s)

Original languageEnglish
Article number110900
Journal / PublicationColloids and Surfaces B: Biointerfaces
Volume190
Online published24 Feb 2020
Publication statusPublished - Jun 2020

Abstract

Antibiotics have played an important role in the treatment of bacteria related infections. However, the rapid emergence of multidrug-resistant bacteria and limited number of antibiotics available is a great challenge to humankind. To address this problem, we are proposing a photosensitizer-modified biodegradable zeolitic imidazolate framework-8 nanocomposite that can kill not only Gram-positive bacteria Staphylococcus aureus, but also methicillin-resistant Staphylococcus aureus (MRSA) with high efficacy. In vivo testing revealed that these nanocomposites are highly effective for in vivo wound disinfection with minimal side-effects. In conclusion, this photosensitizer-modified biodegradable nanocomposite could be very promising for a synergistic antibacterial therapy to overcome MRSA.

Research Area(s)

  • Antibacterial therapy, Photodynamic therapy, Photosensitizer, Zeolitic imidazolate framework 8

Citation Format(s)

Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA). / Li, Juan; Gopal, Ashna; Karaosmanoglu, Sena; Lin, Jiafu; Munshi, Tasnim; Zhang, Wenjun; Chen, Xianfeng; Yan, Li.

In: Colloids and Surfaces B: Biointerfaces, Vol. 190, 110900, 06.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review