Photoregulated uptake and release of drug by an organic-inorganic hybrid sol-gel material

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

17 Scopus Citations
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Author(s)

  • Qian Tang
  • Chengbin Gong
  • Michael Hon-Wah Lam
  • Xiangkai Fu

Detail(s)

Original languageEnglish
Pages (from-to)495-504
Journal / PublicationJournal of Sol-Gel Science and Technology
Volume59
Issue number3
Publication statusPublished - Sept 2011

Abstract

A photo-responsive molecularly imprinted sol-gel organic-inorganic hybrid material prepared by covalent imprinting of the template-functional monomer complex formed between 4,40-dihydroxylazobenzene and ibuprofen was developed to explore the photo-regulated uptake and release of drug by a silicate-based smart molecularly imprinted materials. After imprinting, the template molecules (ibuprofen) were removed via hydrolysis in acid, and accurate cavities were left, which could be used as the receptor recognition sites for ibuprofen. The new organic-inorganic hybrid material shows specific affinity to ibuprofen and reversible uptake and release of ibuprofen upon alternate irradiation at 365 and 440 nm, respectively. The favorable binding strength of the imprinted receptor sites in the molecularly imprinted polymer (MIP) for ibuprofen is found to be 2.28 × 103 M-1. Density of receptor sites in the MIP material was 4.0 lmol/g-MIP. © Springer Science+Business Media, LLC 2010.

Research Area(s)

  • Azobenzene, Ibuprofen, Organic-inorganic hybrid materials, Photo-responsive, Sol-gel

Citation Format(s)

Photoregulated uptake and release of drug by an organic-inorganic hybrid sol-gel material. / Tang, Qian; Gong, Chengbin; Lam, Michael Hon-Wah et al.
In: Journal of Sol-Gel Science and Technology, Vol. 59, No. 3, 09.2011, p. 495-504.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review