Photophysical, Cellular-Uptake, and Bioimaging Studies of Luminescent Ruthenium(II)–Polypyridine Complexes Containing a d-Fructose Pendant

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

4 Scopus Citations
View graph of relations

Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)5288-5294
Journal / PublicationEuropean Journal of Inorganic Chemistry
Volume2017
Issue number44
Online published27 Nov 2017
Publication statusPublished - 1 Dec 2017

Abstract

Two luminescent ruthenium(II)–polypyridine complexes, appended with a d-fructose unit, [Ru(N^N)2(bpy-fructose)](PF6)2 [bpy-fructose = 4-(1-deoxy-d-fructos-1-yl)aminocarbonyl-4′-methyl-2,2′-bipyridine; N^N = 4,7-diphenyl-1,10-phenanthroline (Ph2-phen) (1a) and 2,2′-bipyridine (bpy) (2a)] and their d-fructose-free counterparts [Ru(N^N)2(bpy-Et)](PF6)2 [bpy-Et = 4-(ethylaminocarbonyl)-4′-methyl-2,2′-bipyridine; N^N = Ph2-phen (1b) and bpy (2b)] are synthesized and characterized. The photophysical properties, lipophilicity, cytotoxicity, and cellular uptake of the complexes are studied. Laser-scanning confocal microscopy reveals that both complexes 1a and 1b display intense membrane staining toward human breast adenocarcinoma (MCF-7) cells. However, while complex 1a retains its membrane-staining characteristic when incubated with human cervical epithelioid carcinoma (HeLa) cells, complex 1b is localized in the mitochondria. Additionally, fructose-dependent cellular-uptake experiments suggest that complex 1a is transported into MCF-7 cells through a glucose transporter (GLUT) mediated pathway.

Research Area(s)

  • Bipyridine ligands, d-Fructose, Imaging agents, Luminescence, Ruthenium

Citation Format(s)

Photophysical, Cellular-Uptake, and Bioimaging Studies of Luminescent Ruthenium(II)–Polypyridine Complexes Containing a d-Fructose Pendant. / Lau, Chris Tsan-Shing; Chan, Christina; Zhang, Kenneth Yin; Roy, Vellaisamy A. L.; Lo, Kenneth Kam-Wing.

In: European Journal of Inorganic Chemistry, Vol. 2017, No. 44, 01.12.2017, p. 5288-5294.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal