Photophysical, Cellular-Uptake, and Bioimaging Studies of Luminescent Ruthenium(II)–Polypyridine Complexes Containing a D-Fructose Pendant
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
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Detail(s)
Original language | English |
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Pages (from-to) | 5288-5294 |
Journal / Publication | European Journal of Inorganic Chemistry |
Volume | 2017 |
Issue number | 44 |
Online published | 27 Nov 2017 |
Publication status | Published - 1 Dec 2017 |
Link(s)
Abstract
Two luminescent ruthenium(II)–polypyridine complexes, appended with a d-fructose unit, [Ru(N^N)2(bpy-fructose)](PF6)2 [bpy-fructose = 4-(1-deoxy-d-fructos-1-yl)aminocarbonyl-4′-methyl-2,2′-bipyridine; N^N = 4,7-diphenyl-1,10-phenanthroline (Ph2-phen) (1a) and 2,2′-bipyridine (bpy) (2a)] and their d-fructose-free counterparts [Ru(N^N)2(bpy-Et)](PF6)2 [bpy-Et = 4-(ethylaminocarbonyl)-4′-methyl-2,2′-bipyridine; N^N = Ph2-phen (1b) and bpy (2b)] are synthesized and characterized. The photophysical properties, lipophilicity, cytotoxicity, and cellular uptake of the complexes are studied. Laser-scanning confocal microscopy reveals that both complexes 1a and 1b display intense membrane staining toward human breast adenocarcinoma (MCF-7) cells. However, while complex 1a retains its membrane-staining characteristic when incubated with human cervical epithelioid carcinoma (HeLa) cells, complex 1b is localized in the mitochondria. Additionally, fructose-dependent cellular-uptake experiments suggest that complex 1a is transported into MCF-7 cells through a glucose transporter (GLUT) mediated pathway.
Research Area(s)
- Bipyridine ligands, d-Fructose, Imaging agents, Luminescence, Ruthenium
Citation Format(s)
Photophysical, Cellular-Uptake, and Bioimaging Studies of Luminescent Ruthenium(II)–Polypyridine Complexes Containing a D-Fructose Pendant. / Lau, Chris Tsan-Shing; Chan, Christina; Zhang, Kenneth Yin et al.
In: European Journal of Inorganic Chemistry, Vol. 2017, No. 44, 01.12.2017, p. 5288-5294.
In: European Journal of Inorganic Chemistry, Vol. 2017, No. 44, 01.12.2017, p. 5288-5294.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review