Photonic double-network hydrogel dressings for antibacterial phototherapy and inflammation regulation in the general management of cutaneous regeneration

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Jiyu Sun
  • Yi Deng
  • Qiuyang Han
  • Daichuan Ma
  • Yau Kei Chan
  • Shuai He
  • Hao Wang
  • Xinliang Fu
  • Xueqi Gan

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)609-624
Journal / PublicationNanoscale
Volume15
Issue number2
Online published16 Nov 2022
Publication statusPublished - 14 Jan 2023

Abstract

The treatment of festering pathogenic bacteria-induced skin wounds with increased inflammation is an ongoing challenge. The traditional antibacterial photothermal therapy always results in localized hyperthermia (over 50 °C), which inevitably delays tissue recovery. To address this serious issue, we devise a novel photonic hydrogel by integrating urchin-like Bi2S3 nano-heterojunctions (nano-HJs) into double-network hydrogels for infected skin regeneration. The synergy of NIR-triggered heat and ROS enables the hydrogels to achieve a rapid germicidal efficacy against bacteria within 15 min at mild temperature (below 50 °C). In vitro cell analysis results revealed that the photonic hydrogels exhibit superior cytocompatibility even after NIR illumination. More importantly, an in vivo study demonstrated that the photonic hydrogel dressings have a robust ability of accelerating contagious full-thickness wound regeneration through debriding abscesses, eliminating pathogens, improving collagen deposition, promoting angiogenesis, and adjusting the inflammation state. This photonic hydrogel system provides a general management strategy for the remedy of infectious wounds, where the incorporation of nano-HJs endows the hydrogels with the photodisinfection ability; in addition, the multifunctional hydrogels alleviate the damage from overwhelming heat towards surrounding tissues during phototherapy and steer the inflammation during the process of tissue regeneration. Accordingly, this work highlights the promising application of the photonic hydrogels in conquering refractory pathogen-invaded infection.

Citation Format(s)

Photonic double-network hydrogel dressings for antibacterial phototherapy and inflammation regulation in the general management of cutaneous regeneration. / Sun, Jiyu; Deng, Yi; Han, Qiuyang et al.
In: Nanoscale, Vol. 15, No. 2, 14.01.2023, p. 609-624.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review