Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

Guang-Xi Xu; Eunice Chiu-Lam Mak; Kenneth Kam-Wing Lo

doi:10.1039/d1qi00931a

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

Guang-Xi Xu (Co-first Author)
, Eunice Chiu-Lam Mak (Co-first Author)
, Kenneth Kam-Wing Lo^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

42 Citations (Scopus)

63 Downloads (CityUHK Scholars)

Abstract

By virtue of their rich photophysical and photochemical properties, transition metal complexes (TMCs) have been extensively studied in multidisciplinary research. In this review, recent studies on TMCs for biological applications are described with a focus on the behaviour of TMCs as specific intracellular sensors and organelle-targeting imaging reagents. Some prominent examples of TMCs as photosensitisers for in vitro and in vivo phototherapies, such as photodynamic therapy and photoactivated chemotherapy, are highlighted. Also, future development of TMCs for new diagnostic and therapeutic applications is discussed.

Original language	English
Pages (from-to)	4553-4579
Journal	Inorganic Chemistry Frontiers
Volume	8
Issue number	20
Online published	3 Sept 2021
DOIs	https://doi.org/10.1039/d1qi00931a
Publication status	Published - 21 Oct 2021

Research Keywords

RUTHENIUM(II) POLYPYRIDYL COMPLEXES
IRIDIUM(III) COMPLEXES
PHOTODYNAMIC THERAPY
IMAGING REAGENTS
NITRIC-OXIDE
CANCER-CELLS
PHOTOCHEMICAL PROPERTIES
LUMINESCENT RHENIUM(I)
IR(III) COMPLEXES
FLUORESCENT-PROBE

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This journal is © the Partner Organisations 2021. This is the accepted version of a paper published in Inorganic Chemistry Frontiers. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Xu, G-X., Mak, E. C-L., & Lo, K. K-W. (2021). Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics. Inorganic Chemistry Frontiers, 8(20), 4553-4579. https://doi.org/10.1039/d1qi00931a.

RGC Funding Information

RGC-funded

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10.1039/d1qi00931a

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title = "Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics",

abstract = "By virtue of their rich photophysical and photochemical properties, transition metal complexes (TMCs) have been extensively studied in multidisciplinary research. In this review, recent studies on TMCs for biological applications are described with a focus on the behaviour of TMCs as specific intracellular sensors and organelle-targeting imaging reagents. Some prominent examples of TMCs as photosensitisers for in vitro and in vivo phototherapies, such as photodynamic therapy and photoactivated chemotherapy, are highlighted. Also, future development of TMCs for new diagnostic and therapeutic applications is discussed.",

keywords = "RUTHENIUM(II) POLYPYRIDYL COMPLEXES, IRIDIUM(III) COMPLEXES, PHOTODYNAMIC THERAPY, IMAGING REAGENTS, NITRIC-OXIDE, CANCER-CELLS, PHOTOCHEMICAL PROPERTIES, LUMINESCENT RHENIUM(I), IR(III) COMPLEXES, FLUORESCENT-PROBE",

author = "Guang-Xi Xu and Mak, \{Eunice Chiu-Lam\} and Lo, \{Kenneth Kam-Wing\}",

year = "2021",

month = oct,

day = "21",

doi = "10.1039/d1qi00931a",

language = "English",

volume = "8",

pages = "4553--4579",

journal = "Inorganic Chemistry Frontiers",

issn = "2052-1553",

publisher = "Royal Society of Chemistry",

number = "20",

}

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics. / Xu, Guang-Xi (Co-first Author); Mak, Eunice Chiu-Lam (Co-first Author); Lo, Kenneth Kam-Wing.
In: Inorganic Chemistry Frontiers, Vol. 8, No. 20, 21.10.2021, p. 4553-4579.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

AU - Xu, Guang-Xi

AU - Mak, Eunice Chiu-Lam

AU - Lo, Kenneth Kam-Wing

PY - 2021/10/21

Y1 - 2021/10/21

N2 - By virtue of their rich photophysical and photochemical properties, transition metal complexes (TMCs) have been extensively studied in multidisciplinary research. In this review, recent studies on TMCs for biological applications are described with a focus on the behaviour of TMCs as specific intracellular sensors and organelle-targeting imaging reagents. Some prominent examples of TMCs as photosensitisers for in vitro and in vivo phototherapies, such as photodynamic therapy and photoactivated chemotherapy, are highlighted. Also, future development of TMCs for new diagnostic and therapeutic applications is discussed.

AB - By virtue of their rich photophysical and photochemical properties, transition metal complexes (TMCs) have been extensively studied in multidisciplinary research. In this review, recent studies on TMCs for biological applications are described with a focus on the behaviour of TMCs as specific intracellular sensors and organelle-targeting imaging reagents. Some prominent examples of TMCs as photosensitisers for in vitro and in vivo phototherapies, such as photodynamic therapy and photoactivated chemotherapy, are highlighted. Also, future development of TMCs for new diagnostic and therapeutic applications is discussed.

KW - RUTHENIUM(II) POLYPYRIDYL COMPLEXES

KW - IRIDIUM(III) COMPLEXES

KW - PHOTODYNAMIC THERAPY

KW - IMAGING REAGENTS

KW - NITRIC-OXIDE

KW - CANCER-CELLS

KW - PHOTOCHEMICAL PROPERTIES

KW - LUMINESCENT RHENIUM(I)

KW - IR(III) COMPLEXES

KW - FLUORESCENT-PROBE

UR - http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000700273000001

U2 - 10.1039/d1qi00931a

DO - 10.1039/d1qi00931a

M3 - RGC 21 - Publication in refereed journal

SN - 2052-1553

VL - 8

SP - 4553

EP - 4579

JO - Inorganic Chemistry Frontiers

JF - Inorganic Chemistry Frontiers

IS - 20

ER -

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

Abstract

Research Keywords

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GRF: Exploitation of the Photophysical and Photochemical Properties of Luminescent Transition Metal Complexes as Homo- and Heterobifunctional Crosslinkers for Bioconjugation, Imaging, Photoactivated Therapy, and Fabrication of Biomaterials

GRF: Phosphorogenic Bioorthogonal Probes Derived from Transition Metal Complexes as New Bioimaging Reagents and Photofunctional Therapeutic Agents

GRF: Development of Silsesquioxane-based Molecular Materials Modified with Luminescent Transition Metal Complexes as a New Nanoplatform for Bioimaging and Therapeutic Applications

Cite this

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

Abstract

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

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GRF: Exploitation of the Photophysical and Photochemical Properties of Luminescent Transition Metal Complexes as Homo- and Heterobifunctional Crosslinkers for Bioconjugation, Imaging, Photoactivated Therapy, and Fabrication of Biomaterials

GRF: Phosphorogenic Bioorthogonal Probes Derived from Transition Metal Complexes as New Bioimaging Reagents and Photofunctional Therapeutic Agents

GRF: Development of Silsesquioxane-based Molecular Materials Modified with Luminescent Transition Metal Complexes as a New Nanoplatform for Bioimaging and Therapeutic Applications

Cite this