Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Overview

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Author(s)

Yun-Wah Lam

Related Research Unit(s)

Detail(s)

Original language	English
Article number	10162
Journal / Publication	Chemical Communications
Volume	58
Issue number	73
Online published	8 Aug 2022
Publication status	Published - 18 Sep 2022

Link(s)

DOI	DOI https://doi.org/10.1039/d2cc02405e Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85136978489&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(ef817df9-78e4-46bc-b0d4-15561964c90d).html

Abstract

We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

Research Area(s)

LABELING REAGENTS, LUMINESCENT, CONJUGATION, PEPTIDES, PROTEINS, RECEPTOR

Citation Format(s)

[ RIS ] [ BibTeX ]

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. / Huang, Lili ; Leung, Peter Kam-Keung ; Lee, Lawrence Cho-Cheung et al.

In: Chemical Communications, Vol. 58, No. 73, 10162, 18.09.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Huang, L , Leung, PK-K , Lee, LC-C , Xu, G-X, Lam, Y-W & Lo, KK-W 2022, 'Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications', Chemical Communications, vol. 58, no. 73, 10162. https://doi.org/10.1039/d2cc02405e

Huang, L., Leung, P. K-K., Lee, L. C-C., Xu, G-X., Lam, Y-W., & Lo, K. K-W. (2022). Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. Chemical Communications, 58(73), [10162]. https://doi.org/10.1039/d2cc02405e

Huang L , Leung PK-K , Lee LC-C , Xu G-X, Lam Y-W, Lo KK-W. Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. Chemical Communications. 2022 Sep 18;58(73):10162. Epub 2022 Aug 8. doi: 10.1039/d2cc02405e

Huang, Lili ; Leung, Peter Kam-Keung ; Lee, Lawrence Cho-Cheung et al. / Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. In: Chemical Communications. 2022 ; Vol. 58, No. 73.