Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Lili Huang; Peter Kam-Keung Leung; Lawrence Cho-Cheung Lee; Guang-Xi Xu; Yun-Wah Lam; Kenneth Kam-Wing Lo

doi:10.1039/d2cc02405e

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Lili Huang, Peter Kam-Keung Leung, Lawrence Cho-Cheung Lee, Guang-Xi Xu, Yun-Wah Lam^*, Kenneth Kam-Wing Lo^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

17 Citations (Scopus)

54 Downloads (CityUHK Scholars)

Abstract

We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

Original language	English
Pages (from-to)	10162-10165
Journal	Chemical Communications
Volume	58
Issue number	73
Online published	8 Aug 2022
DOIs	https://doi.org/10.1039/d2cc02405e
Publication status	Published - 18 Sept 2022

Funding

We thank the Hong Kong Research Grants Council (Project No. CityU 11300019, CityU 11302820, CityU 11301121, T42- 103/16-N, C7075-21GF and N_CityU104/21) for financial support. We also thank the funding support from “Laboratory for Synthetic Chemistry and Chemical Biology” under the Health@InnoHK Program launched by Innovation and Technology Commission, The Government of Hong Kong SAR, P. R. China. Lili Huang acknowledges the receipt of a Postgraduate Studentship administered by City University of Hong Kong.

Research Keywords

LABELING REAGENTS
LUMINESCENT
CONJUGATION
PEPTIDES
PROTEINS
RECEPTOR

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This journal is © The Royal Society of Chemistry 2022. This is the accepted version of a paper published in Chemical Communications. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Huang, L., Leung, P. K-K., Lee, L. C-C., Xu, G-X., Lam, Y-W., & Lo, K. K-W. (2022). Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. Chemical Communications, 58(73), [10162]. https://doi.org/10.1039/d2cc02405e.

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title = "Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications",

abstract = "We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.",

keywords = "LABELING REAGENTS, LUMINESCENT, CONJUGATION, PEPTIDES, PROTEINS, RECEPTOR",

author = "Lili Huang and Leung, {Peter Kam-Keung} and Lee, {Lawrence Cho-Cheung} and Guang-Xi Xu and Yun-Wah Lam and Lo, {Kenneth Kam-Wing}",

year = "2022",

month = sep,

day = "18",

doi = "10.1039/d2cc02405e",

language = "English",

volume = "58",

pages = "10162--10165",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "73",

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Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. / Huang, Lili ; Leung, Peter Kam-Keung ; Lee, Lawrence Cho-Cheung et al.
In: Chemical Communications, Vol. 58, No. 73, 18.09.2022, p. 10162-10165.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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AU - Leung, Peter Kam-Keung

AU - Lee, Lawrence Cho-Cheung

AU - Xu, Guang-Xi

AU - Lam, Yun-Wah

AU - Lo, Kenneth Kam-Wing

PY - 2022/9/18

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AB - We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

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KW - LUMINESCENT

KW - CONJUGATION

KW - PEPTIDES

KW - PROTEINS

KW - RECEPTOR

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ER -

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

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NSFC: Design and Preparation of Phosphorescent Lifetime-Responsive Polymeric Probes for Enzyme Targeting and Catalytic Activity Sensing in Living Cells

GRF: Modulation of the Luminescence Properties and Photocytotoxic Activity of Transition Metal Complexes through Dissociative Bioorthogonal Reactions for Diagnostic and Therapeutic Applications

GRF: Exploitation of the Photophysical and Photochemical Properties of Luminescent Transition Metal Complexes as Homo- and Heterobifunctional Crosslinkers for Bioconjugation, Imaging, Photoactivated Therapy, and Fabrication of Biomaterials

Cite this

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

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Permanent Link

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Projects

NSFC: Design and Preparation of Phosphorescent Lifetime-Responsive Polymeric Probes for Enzyme Targeting and Catalytic Activity Sensing in Living Cells

GRF: Modulation of the Luminescence Properties and Photocytotoxic Activity of Transition Metal Complexes through Dissociative Bioorthogonal Reactions for Diagnostic and Therapeutic Applications

GRF: Exploitation of the Photophysical and Photochemical Properties of Luminescent Transition Metal Complexes as Homo- and Heterobifunctional Crosslinkers for Bioconjugation, Imaging, Photoactivated Therapy, and Fabrication of Biomaterials

Cite this