Photodynamic inactivation of bacteria and viruses using two monosubstituted zinc(II) phthalocyanines
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 278-283 |
Journal / Publication | European Journal of Medicinal Chemistry |
Volume | 84 |
Publication status | Published - 12 Sep 2014 |
Externally published | Yes |
Link(s)
Abstract
A zinc(II) phthalocyanine substituted with a triamino moiety and its tri-N-methylated analogue have been prepared and characterized with various spectroscopic methods. Both compounds remain non-aggregated in N,N-dimethylformamide and in water containing 0.05% Cremophor EL (v/v), and can generate singlet oxygen effectively. The photodynamic activities of these compounds have been examined against a range of bacterial strains, including the Gram-positive methicillin-sensitive Staphylococcus aureus ATCC 25923 and methicillin-resistant Staphylococcus aureus ATCC BAA-43, and the Gram-negative Escherichia coli ATCC 35218 and Pseudomonas aeruginosa ATCC 27853. Both photosensitizers are highly cytotoxic, particularly for the two Gram-positive strains, for which as low as 5 nM of dye is required to induce a 4-log reduction of their viability. The tri-N-methylated derivative has also been shown to be able to effectively inhibit the growth of a series of clinical strains of Staphylococcus aureus and Escherichia coli, and biofilms of methicillin- resistant Staphylococcus aureus ATCC 67928 and ATCC 68507, and Staphylococcus epidermidis ATCC 35984. In addition, the photodynamic inactivation of a range of viruses using these two compounds has also been investigated. Both compounds are highly photocytotoxic against the enveloped viruses influenza A virus (H1N1) and herpes simplex virus type 1 (HSV1), but exhibit no significant cytotoxicity toward the non-enveloped viruses adenovirus type 3 (Ad3) and coxsackievirus (Cox B1). © 2014 Elsevier Masson SAS. All rights reserved.
Research Area(s)
- Antimicrobial photodynamic therapy, Bacteria, Photosensitizer, Phthalocyanine, Singlet oxygen
Citation Format(s)
Photodynamic inactivation of bacteria and viruses using two monosubstituted zinc(II) phthalocyanines. / Ke, Mei-Rong; Eastel, Jennifer Mary; Ngai, Karry L.K.; Cheung, Yuk-Yam; Chan, Paul K.S.; Hui, Mamie; Ng, Dennis K.P.; Lo, Pui-Chi.
In: European Journal of Medicinal Chemistry, Vol. 84, 12.09.2014, p. 278-283.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review