Photodynamic inactivation of bacteria and viruses using two monosubstituted zinc(II) phthalocyanines

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Mei-Rong Ke
  • Jennifer Mary Eastel
  • Karry L.K. Ngai
  • Yuk-Yam Cheung
  • Paul K.S. Chan
  • Mamie Hui
  • Dennis K.P. Ng

Detail(s)

Original languageEnglish
Pages (from-to)278-283
Journal / PublicationEuropean Journal of Medicinal Chemistry
Volume84
Publication statusPublished - 12 Sep 2014
Externally publishedYes

Abstract

A zinc(II) phthalocyanine substituted with a triamino moiety and its tri-N-methylated analogue have been prepared and characterized with various spectroscopic methods. Both compounds remain non-aggregated in N,N-dimethylformamide and in water containing 0.05% Cremophor EL (v/v), and can generate singlet oxygen effectively. The photodynamic activities of these compounds have been examined against a range of bacterial strains, including the Gram-positive methicillin-sensitive Staphylococcus aureus ATCC 25923 and methicillin-resistant Staphylococcus aureus ATCC BAA-43, and the Gram-negative Escherichia coli ATCC 35218 and Pseudomonas aeruginosa ATCC 27853. Both photosensitizers are highly cytotoxic, particularly for the two Gram-positive strains, for which as low as 5 nM of dye is required to induce a 4-log reduction of their viability. The tri-N-methylated derivative has also been shown to be able to effectively inhibit the growth of a series of clinical strains of Staphylococcus aureus and Escherichia coli, and biofilms of methicillin- resistant Staphylococcus aureus ATCC 67928 and ATCC 68507, and Staphylococcus epidermidis ATCC 35984. In addition, the photodynamic inactivation of a range of viruses using these two compounds has also been investigated. Both compounds are highly photocytotoxic against the enveloped viruses influenza A virus (H1N1) and herpes simplex virus type 1 (HSV1), but exhibit no significant cytotoxicity toward the non-enveloped viruses adenovirus type 3 (Ad3) and coxsackievirus (Cox B1). © 2014 Elsevier Masson SAS. All rights reserved.

Research Area(s)

  • Antimicrobial photodynamic therapy, Bacteria, Photosensitizer, Phthalocyanine, Singlet oxygen

Citation Format(s)

Photodynamic inactivation of bacteria and viruses using two monosubstituted zinc(II) phthalocyanines. / Ke, Mei-Rong; Eastel, Jennifer Mary; Ngai, Karry L.K.; Cheung, Yuk-Yam; Chan, Paul K.S.; Hui, Mamie; Ng, Dennis K.P.; Lo, Pui-Chi.

In: European Journal of Medicinal Chemistry, Vol. 84, 12.09.2014, p. 278-283.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal