Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

105 Scopus Citations
View graph of relations

Author(s)

  • Quansan Yang
  • Tong Wei
  • Rose T. Yin
  • Mingzheng Wu
  • Yameng Xu
  • Jahyun Koo
  • Yeon Sik Choi
  • Zhaoqian Xie
  • Sheena W. Chen
  • Irawati Kandela
  • Shenglian Yao
  • Yujun Deng
  • Raudel Avila
  • Tzu-Li Liu
  • Wubin Bai
  • Yiyuan Yang
  • Mengdi Han
  • Qihui Zhang
  • Chad R. Haney
  • K. Benjamin Lee
  • Kedar Aras
  • Tong Wang
  • Min-Ho Seo
  • Haiwen Luan
  • Seung Min Lee
  • Anlil Brikha
  • Nayereh Ghoreishi-Haack
  • Lori Tran
  • Iwona Stepien
  • Fraser Aird
  • Emily A. Waters
  • Anthony Banks
  • Gregory D. Trachiotis
  • John M. Torkelson
  • Yonggang Huang
  • Yevgenia Kozorovitskiy
  • Igor R. Efimov
  • John A. Rogers

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)1559–1570
Journal / PublicationNature Materials
Volume20
Issue number11
Online published29 Jul 2021
Publication statusPublished - Nov 2021

Abstract

Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic–tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. These materials strongly bond both to the surfaces of the devices and to those of different internal organs, with stable adhesion for several days to months, in chemistries that can be tailored to bioresorb at controlled rates. Experimental demonstrations in live animal models include device applications that range from battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy to wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays. These advances have immediate applicability across nearly all types of bioelectronic/optoelectronic system currently used in animal model studies, and they also have the potential for future treatment of life-threatening diseases and disorders in humans.

Citation Format(s)

Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues. / Yang, Quansan; Wei, Tong; Yin, Rose T. et al.
In: Nature Materials, Vol. 20, No. 11, 11.2021, p. 1559–1570.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review