Photoactivation of core-shell titania coated upconversion nanoparticles and their effect on cell death

Niagara Muhammad Idris; Sasidharan Swarnalatha Lucky; Zhengquan Li; Kai Huang; Yong Zhang

doi:10.1039/c4tb01169d

Photoactivation of core-shell titania coated upconversion nanoparticles and their effect on cell death

Niagara Muhammad Idris
, Sasidharan Swarnalatha Lucky
, Zhengquan Li
, Kai Huang
, Yong Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

86 Citations (Scopus)

Abstract

Titania (TiO₂) has been explored as a potential drug in eradicating cancer by virtue of its photocatalytic property to generate reactive oxygen species (ROS) under UV irradiation. Its clinical application, however, has been hampered by the tissue penetration depth limit of the UV light needed for its activation. The use of 'invisible' near-infrared (NIR) light affords greater tissue penetration depth because most tissues are 'transparent' to NIR light. Here, we uniformly coated TiO₂ to a nanometer-sized light transducer that can upconvert highly penetrating NIR light to the activation absorption spectrum of TiO₂ at UV range. Under NIR excitation, photoinduced TiO₂ by the upconverted UV light results in the generation of more than one type of ROS that was stably produced under an appropriate storage condition. The amount of ROS produced was also effective in killing cancer cells in vitro, thus suggesting its potential in overcoming the current penetration depth limit. This journal is © the Partner Organisations 2014.

Original language	English
Pages (from-to)	7017-7026
Journal	Journal of Materials Chemistry B
Volume	2
Issue number	40
DOIs	https://doi.org/10.1039/c4tb01169d
Publication status	Published - 2014
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

We thank S. H. Q. Chan (Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore) for working on the stability and type of ROS produced as well as Dr Wang Hanjie and Dr Liu Jinliang for preparing the TEM image. We acknowledge financial support from Singapore Agency for Science, Technology and Research (A*STAR) Biomedical Engineering Programme (grant R-397-000-128-305) and National University of Singapore. S. S. Lucky is a recipient of NGS scholarship from NUS graduate school (NGS) for Integrative Sciences and Engineering, National University of Singapore.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "Photoactivation of core-shell titania coated upconversion nanoparticles and their effect on cell death",

abstract = "Titania (TiO2) has been explored as a potential drug in eradicating cancer by virtue of its photocatalytic property to generate reactive oxygen species (ROS) under UV irradiation. Its clinical application, however, has been hampered by the tissue penetration depth limit of the UV light needed for its activation. The use of 'invisible' near-infrared (NIR) light affords greater tissue penetration depth because most tissues are 'transparent' to NIR light. Here, we uniformly coated TiO2 to a nanometer-sized light transducer that can upconvert highly penetrating NIR light to the activation absorption spectrum of TiO2 at UV range. Under NIR excitation, photoinduced TiO2 by the upconverted UV light results in the generation of more than one type of ROS that was stably produced under an appropriate storage condition. The amount of ROS produced was also effective in killing cancer cells in vitro, thus suggesting its potential in overcoming the current penetration depth limit. This journal is {\textcopyright} the Partner Organisations 2014.",

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AU - Lucky, Sasidharan Swarnalatha

AU - Li, Zhengquan

AU - Huang, Kai

AU - Zhang, Yong

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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N2 - Titania (TiO2) has been explored as a potential drug in eradicating cancer by virtue of its photocatalytic property to generate reactive oxygen species (ROS) under UV irradiation. Its clinical application, however, has been hampered by the tissue penetration depth limit of the UV light needed for its activation. The use of 'invisible' near-infrared (NIR) light affords greater tissue penetration depth because most tissues are 'transparent' to NIR light. Here, we uniformly coated TiO2 to a nanometer-sized light transducer that can upconvert highly penetrating NIR light to the activation absorption spectrum of TiO2 at UV range. Under NIR excitation, photoinduced TiO2 by the upconverted UV light results in the generation of more than one type of ROS that was stably produced under an appropriate storage condition. The amount of ROS produced was also effective in killing cancer cells in vitro, thus suggesting its potential in overcoming the current penetration depth limit. This journal is © the Partner Organisations 2014.

AB - Titania (TiO2) has been explored as a potential drug in eradicating cancer by virtue of its photocatalytic property to generate reactive oxygen species (ROS) under UV irradiation. Its clinical application, however, has been hampered by the tissue penetration depth limit of the UV light needed for its activation. The use of 'invisible' near-infrared (NIR) light affords greater tissue penetration depth because most tissues are 'transparent' to NIR light. Here, we uniformly coated TiO2 to a nanometer-sized light transducer that can upconvert highly penetrating NIR light to the activation absorption spectrum of TiO2 at UV range. Under NIR excitation, photoinduced TiO2 by the upconverted UV light results in the generation of more than one type of ROS that was stably produced under an appropriate storage condition. The amount of ROS produced was also effective in killing cancer cells in vitro, thus suggesting its potential in overcoming the current penetration depth limit. This journal is © the Partner Organisations 2014.

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DO - 10.1039/c4tb01169d

M3 - RGC 21 - Publication in refereed journal

SN - 2050-7518

VL - 2

SP - 7017

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JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 40

ER -

Photoactivation of core-shell titania coated upconversion nanoparticles and their effect on cell death

Abstract

Bibliographical note

Funding

UN SDGs

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