Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Detail(s)

Original languageEnglish
Pages (from-to)4557-4560
Journal / PublicationChemical Communications
Volume52
Issue number24
Online published24 Feb 2016
Publication statusPublished - 25 Mar 2016

Abstract

Two novel photoactivatable mitochondria-targeting luminescent iridium(iii) poly(ethylene glycol) (PEG) complexes incorporated with a nitrobenzyl group were designed. They showed minimal cytotoxic activity in the dark, but became significantly cytotoxic upon irradiation due to the release of the PEG pendants.

Citation Format(s)

Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage. / Tso, Karson Ka-Shun; Leung, Kam-Keung; Liu, Hua-Wei; Lo, Kenneth Kam-Wing.

In: Chemical Communications, Vol. 52, No. 24, 25.03.2016, p. 4557-4560.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal