PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Ching-Yi Chen
  • Tae Hee Kim
  • Wen-Chung Wu
  • Chi-Ming Huang
  • Hua Wei
  • Christopher W. Mount
  • Yanqing Tian
  • Sei-Hum Jang
  • Suzie H. Pun

Detail(s)

Original languageEnglish
Pages (from-to)4501-4509
Journal / PublicationBiomaterials
Volume34
Issue number18
Publication statusPublished - Jun 2013
Externally publishedYes

Abstract

Polymeric micelles are promising carriers for anti-cancer agents due to their small size, ease of assembly, and versatility for functionalization. A current challenge in the use of polymeric micelles is the sensitive balance that must be achieved between stability during prolonged blood circulation and release of active drug at the tumor site. Stimuli-responsive materials provide a mechanism for triggered drug release in the acidic tumor and intracellular microenvironments. In this work, we synthesized a series of dual pH- and temperature-responsive block copolymers containing a poly(ε-caprolactone) (PCL) hydrophobic block with a poly(triethylene glycol) block that were copolymerized with an amino acid-functionalized monomer. The block copolymers formed micellar structures in aqueous solutions. An optimized polymer that was functionalized with 6-aminocaproic acid (ACA) possessed pH-sensitive phase transitions at mildly acidic pH and body temperature. Doxorubicin-loaded micelles formed from these polymers were stable at blood pH (~7.4) and showed increased drug release at acidic pH. In addition, these micelles displayed more potent anti-cancer activity than free doxorubicin when tested in a tumor xenograft model in mice. © 2013 Elsevier Ltd.

Research Area(s)

  • Anti-cancer, PH-sensitive, Polymeric micelle, Temperature sensitive, Tumor delivery

Citation Format(s)

PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. / Chen, Ching-Yi; Kim, Tae Hee; Wu, Wen-Chung; Huang, Chi-Ming; Wei, Hua; Mount, Christopher W.; Tian, Yanqing; Jang, Sei-Hum; Pun, Suzie H.; Jen, Alex K.-Y.

In: Biomaterials, Vol. 34, No. 18, 06.2013, p. 4501-4509.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal