PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors

Ching-Yi Chen; Tae Hee Kim; Wen-Chung Wu; Chi-Ming Huang; Hua Wei; Christopher W. Mount; Yanqing Tian; Sei-Hum Jang; Suzie H. Pun; Alex K.-Y. Jen

doi:10.1016/j.biomaterials.2013.02.049

Author(s)

Ching-Yi Chen
Tae Hee Kim
Wen-Chung Wu
Chi-Ming Huang
Hua Wei
Christopher W. Mount
Yanqing Tian
Sei-Hum Jang
Suzie H. Pun

Detail(s)

Original language	English
Pages (from-to)	4501-4509
Journal / Publication	Biomaterials
Volume	34
Issue number	18
Publication status	Published - Jun 2013
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.biomaterials.2013.02.049 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84875633511&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(5c306528-cb6f-44ca-a647-dcd2cac8684b).html

Abstract

Polymeric micelles are promising carriers for anti-cancer agents due to their small size, ease of assembly, and versatility for functionalization. A current challenge in the use of polymeric micelles is the sensitive balance that must be achieved between stability during prolonged blood circulation and release of active drug at the tumor site. Stimuli-responsive materials provide a mechanism for triggered drug release in the acidic tumor and intracellular microenvironments. In this work, we synthesized a series of dual pH- and temperature-responsive block copolymers containing a poly(ε-caprolactone) (PCL) hydrophobic block with a poly(triethylene glycol) block that were copolymerized with an amino acid-functionalized monomer. The block copolymers formed micellar structures in aqueous solutions. An optimized polymer that was functionalized with 6-aminocaproic acid (ACA) possessed pH-sensitive phase transitions at mildly acidic pH and body temperature. Doxorubicin-loaded micelles formed from these polymers were stable at blood pH (~7.4) and showed increased drug release at acidic pH. In addition, these micelles displayed more potent anti-cancer activity than free doxorubicin when tested in a tumor xenograft model in mice. © 2013 Elsevier Ltd.

Research Area(s)

Anti-cancer, PH-sensitive, Polymeric micelle, Temperature sensitive, Tumor delivery

Citation Format(s)

[ RIS ] [ BibTeX ]

PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. / Chen, Ching-Yi; Kim, Tae Hee; Wu, Wen-Chung et al.

In: Biomaterials, Vol. 34, No. 18, 06.2013, p. 4501-4509.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Chen, C-Y, Kim, TH, Wu, W-C, Huang, C-M, Wei, H, Mount, CW, Tian, Y, Jang, S-H, Pun, SH & Jen, AK-Y 2013, 'PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors', Biomaterials, vol. 34, no. 18, pp. 4501-4509. https://doi.org/10.1016/j.biomaterials.2013.02.049

Chen, C-Y., Kim, T. H., Wu, W-C., Huang, C-M., Wei, H., Mount, C. W., Tian, Y., Jang, S-H., Pun, S. H., & Jen, A. K-Y. (2013). PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. Biomaterials, 34(18), 4501-4509. https://doi.org/10.1016/j.biomaterials.2013.02.049

Chen C-Y, Kim TH, Wu W-C, Huang C-M, Wei H, Mount CW et al. PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. Biomaterials. 2013 Jun;34(18):4501-4509. doi: 10.1016/j.biomaterials.2013.02.049

Chen, Ching-Yi ; Kim, Tae Hee ; Wu, Wen-Chung et al. / PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. In: Biomaterials. 2013 ; Vol. 34, No. 18. pp. 4501-4509.